CGP
13 July 2015 to 18 December 2015
The aim of this six-month research programme is to create a unique forum to strengthen and develop research links between state-of-the-art experimental "wet" sciences (biology, medicine, bio-physics) and theoretical "dry" sciences (pure, applied and computational mathematics, theoretical physics, statistics). In this programme we will discuss and present in a hands-on format current experimental methodology for cell motility and pattern formation. We will emphasise interactions between experimentalists and theoreticians, with the dual goals of understanding how current mathematical techniques from physics, differential geometry, mathematical modelling and numerical analysis can help to understand current problems in the areas of cell motility and pattern formation, and what new mathematical techniques may emerge in the process.
The research programme will commence with an initial 10-day research-lecture-intensive Postgraduate Advanced Study Institute in Mathematical and Physical Sciences (PASI-MPS). The objective of this introductory course is to introduce major concepts, approaches and current challenges in the different disciplines investigating cell motility and pattern formation. The PASI-MPS will be followed by a week-long workshop that will offer participants a "hands on" opportunity to experience current experimental techniques in laboratories at the Institute of Molecular and Cellular Anatomy, RWTH Aachen University and the Institute of Complex Systems Biomechanics, Juelich in Germany. Specific bench-mark research questions, based on experimentally acquired data, will be formulated and addressed which will form the basis of the work during the remainder of the programme. These instructional events will be followed by three workshops covering different aspects of cell mechanics, morphogenesis, pattern formation and new mathematical and computational approaches to describe these phenomena. All workshops will combine experiments, modelling, analysis, simulations and applications. Our research programme will beam real-time lectures and experimental demonstrations in laboratories and research institutes and centres from around the world, to lecture halls at the Isaac Newton Institute.
These activities aim to foster interactions and discussions among participants and disseminate new techniques and results. Each of the workshops will focus on cross-fertilisation between the proposed research areas in order to bring world-leading expertise to a single forum for rapid dissemination of results and exchange of ideas. There will be a one-day Open for Business event to take place during the last workshop in order to bring to the forum industrial partners, non-governmental organisations and other interested stakeholders.
The Institute kindly requests that any papers published as a result of this programme’s activities are credited as such. Please acknowledge the support of the Institute in your paper using the following text:
The author(s) would like to thank the Isaac Newton Institute for Mathematical Sciences, Cambridge, for support and hospitality during the programme Coupling geometric PDEs with physics for cell morphology, motility and pattern formation, where work on this paper was undertaken. This work was supported by EPSRC grant EP/K032208/1.
Click here to download the programme's final scientific report
Title | Year | Programme | Publication Date |
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A note on how to develop interdisciplinary collaborations between experimentalists and theoreticiansAuthors: Anotida Madzvamuse, Sharon Lubkin |
2015 | CGP | 21 October 2022 |
Global existence for a degenerate haptotaxis model of tumor invasion under the go-or-grow dichotomy hypothesisAuthors: Anna Zhigun, Alexander Hunt, 15964 |
2015 | CGP | 2 March 2017 |
A nonlocal sample dependence SDE-PDE system modeling proton dynamics in a tumorAuthors: Peter Kloeden, Stefanie Sonner, 15964 |
2015 | CGP | 2 March 2017 |
Geometry can provide long-range mechanical guidance for embryogenesisAuthors: Pierre Saramito, Jocelyn Etienne, Mahamar Dicko |
2015 | CGP | 2 March 2017 |
Simulating Organogenesis in COMSOL: Phase-Field Based Simulations of Embryonic Lung Branching MorphogenesisAuthors: Dagmar Iber, Lucas D. Wittwer, Roberto Croce, Sebastian Aland |
2015 | CGP | 2 March 2017 |
A mathematical model of GTPase pattern formation during single-cell wound repairAuthors: William Bement, 15922, William R Holmes |
2015 | CGP | 2 March 2017 |
Numerical treatment of the filament based lamellipodium model (FBLM)Authors: Angelika Manhart, D Oelz, Christian Schmeiser, N Sfakianakis |
2015 | CGP | 21 October 2016 |
Decay to equilibrium of the filament end density along the leading edge of the lamellipodiumAuthors: Angelika Manhart, Christian Schmeiser |
2015 | CGP | 21 October 2016 |
Fractional-diffusion-advection limit of a kinetic modelAuthors: Pedro Aceves-Sánchez, C Shmeiser |
2015 | CGP | 21 October 2016 |
A model for selection of eyespots on butterfly wingsAuthors: T Sekimura, Mirna Golubic Venkataraman, A Madzvamuse |
2015 | CGP | 21 October 2016 |
Reshaping nemato-elastic sheetsAuthors: AP Zakharov, Len Pismen |
2015 | CGP | 21 October 2016 |
A mechanistic collective cell model for epithelial colony growth and contact inhibitionAuthors: Sebastian Aland, H Hatzikirou, John Lowengrub, Axel Voigt |
2015 | CGP | 21 October 2016 |
Numerical simulation of endocytosis: Viscous flow driven by membranes with non-uniformly distrubuted curvature-inducing moleculesAuthors: Sebastian Aland, J Allard, John Lowengrub |
2015 | CGP | 21 October 2016 |
Modeling the mechanosensitivity of neutrophils passing through a narrow channelAuthors: T Wu, James Feng |
2015 | CGP | 21 October 2016 |
A biomechanical model for cell polarization and intercalation during $\it Drosophila$ germband extensionAuthors: H Lan, Q Wang, R Fernandez-Gonzalez, James Feng |
2015 | CGP | 21 October 2016 |
Mesoscopic description of random walks on combsAuthors: V Mendez, A Iomin, D Campos, W Horsthemke |
2015 | CGP | 21 October 2016 |
Does ultra-slow diffusion survive in a three dimensional cylindrical combAuthors: A Iomin, V Mendez |
2015 | CGP | 21 October 2016 |
Characterization of stationary states in random walks with stochastic resettingAuthors: V Mendez, D Campos |
2015 | CGP | 21 October 2016 |
Emergent material properties of developing epithelial tissuesAuthors: PF Machado, J Duque, Jocelyn Etienne, A Martinez-Arias, GB Blanchard, ET Al |
2015 | CGP | 21 October 2016 |
Cells as liquid motors: Mechanosensitivity emerges from collective dynamics of actomyosin cortexAuthors: Jocelyn Etienne, J Fouchard, D Mitrossilis, N Bufi, P Durand-Smet, ET Al |
2015 | CGP | 21 October 2016 |
Initial dynamics of cell spreading are goverened by dissipation in the actin cortexAuthors: Jocelyn Etienne, A Duperray |
2015 | CGP | 21 October 2016 |
On algorithms with good mesh properties for problems with moving boundaries based on the Harmonic Map Heat Flow and the DeTurck trickAuthors: CM Elliott, Hans Fritz |
2015 | CGP | 21 October 2016 |
Coupled bulk-surface free boundary problems arising from a mathematical model of receptor-ligand dynamicsAuthors: CM Elliott, Tom Ranner, Mirna Golubic Venkataraman |
2015 | CGP | 21 October 2016 |
A hyrdrodynamic limit for chemotaxis in a given heterogeneous environmentAuthors: S Grosskinsky, D Marahrens, Angela Stevens |
2015 | CGP | 21 October 2016 |
Stability analysis of reaction-diffusion models on evolving domains: the effects of cross-diffusionAuthors: A Madzvamuse, HS Ndakwo, Raquel Barreira |
2015 | CGP | 21 October 2016 |
The bulk-surface finite element method for reaction-diffusion systems on stationary volumesAuthors: A Madzvamuse, AHW Chung |
2015 | CGP | 21 October 2016 |
Curve shortening flow coupled to lateral diffusionAuthors: Paola Pozzi, Bjorn Stinner |
2015 | CGP | 21 October 2016 |
13 July 2015 to 24 July 2015
27 July 2015 to 31 July 2015
14 September 2015 to 18 September 2015
4 November 2015 to 6 November 2015
7 December 2015 to 11 December 2015
Tuesday 11th August 2015 | |||
---|---|---|---|
11:00 to 12:00 | Room 2 |
Thursday 20th August 2015 | |||
---|---|---|---|
11:00 to 12:00 |
Non-Markovian Reaction-Transport: Modelling Biological Invasions |
Room 2 |
Wednesday 26th August 2015 | |||
---|---|---|---|
11:00 to 12:30 |
Theoretical model for persistent and oscillatory cell motility |
Room 2 |
Thursday 27th August 2015 | |||
---|---|---|---|
11:00 to 12:00 |
Lonely in a group: Single and collective cell behaviour in 3D environments |
Room 2 |
Tuesday 1st September 2015 | |||
---|---|---|---|
11:00 to 12:00 |
Existence and Stability of Spike Clusters for Reaction-Diffusion Systems |
Room 2 |
Thursday 10th September 2015 | |||
---|---|---|---|
11:00 to 12:30 |
Minimising a relaxed Willmore functional for graphs subject to Dirichlet boundary conditions |
Room 2 |
Monday 14th September 2015 | |||
---|---|---|---|
17:00 to 18:00 | No Room Required |
Tuesday 29th September 2015 | |||
---|---|---|---|
11:00 to 12:30 | Room 2 |
Thursday 1st October 2015 | |||
---|---|---|---|
11:00 to 12:30 |
Parallel multigrid methods for parabolic partial differential equations and applications |
Room 2 |
Tuesday 6th October 2015 | |||
---|---|---|---|
11:00 to 12:30 | Room 2 |
Thursday 8th October 2015 | |||
---|---|---|---|
11:00 to 12:30 | Room 2 |
Tuesday 13th October 2015 | |||
---|---|---|---|
11:00 to 12:30 |
Morphogenetic models: from genetic regulatory networks to phenotypes |
Room 2 |
Thursday 22nd October 2015 | |||
---|---|---|---|
09:00 to 10:00 | Room 1 |
Thursday 29th October 2015 | |||
---|---|---|---|
11:00 to 12:30 | Room 2 |
Tuesday 10th November 2015 | |||
---|---|---|---|
11:00 to 12:30 |
Mathematical modelling of a cereal killer: Modelling plant cell invasion by the rice blast fungus |
Room 2 |
Thursday 12th November 2015 | |||
---|---|---|---|
11:00 to 12:30 | Room 2 |
Tuesday 17th November 2015 | |||
---|---|---|---|
11:00 to 12:30 |
A hybrid model to test mechanical cues driving cell migration in angiogenesis |
Room 2 |
Thursday 19th November 2015 | |||
---|---|---|---|
11:00 to 12:30 | Room 2 | ||
16:00 to 17:00 | Room 2 |
Tuesday 24th November 2015 | |||
---|---|---|---|
11:00 to 12:30 |
Discrete and continuous modelling of cell mechanics: from adhesion to migration |
Room 2 |
Thursday 26th November 2015 | |||
---|---|---|---|
11:00 to 12:30 |
A Bayesian approach to parameter identification in Turing systems |
Room 2 |
Tuesday 1st December 2015 | |||
---|---|---|---|
11:00 to 12:30 | Room 2 |
Tuesday 15th December 2015 | |||
---|---|---|---|
14:00 to 15:00 | Discussion Room |
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