This external experimental workshop will be based in the laboratories at the FZJ (Institute of Complex Systems 7: Biomechanics) and RWTH Aachen University (Institute of Molecular and Cellular Anatomy).
Numerical methods are central for simulating, understanding, and predicting fundamental processes during cell migration. The better these methods express the basic and underlying cell aspects, the more meaningful simulations and theoretical predictions are. In order to define the most relevant cell parameters for subsequent modelling-based approaches, this one-week workshop will focus on cell biological experiments using motile epithelial cells. Special focus will be on the structural components such as cytoskeleton and adhesion and on the dynamic processes during aggregate and pattern formation, and cell polarization. Various cytoskeletal structures relevant for the different modes of cell migration will be analysed by different microscopy techniques in living cells and by immunocytochemistry. Methods characterising biochemical processes and biomechanical cell properties and functions will be included and performed at the single cell and multicellular levels. This workshop will expose participants to cutting-edge experimental training associated with cell migration in two and three dimensions; the course includes intense experimental traineeship and intends to deepen the basic understanding of state-of-the-art techniques to examine cell motility.
This external meeting will take place in the laboratories of the Institute of Complex Systems at the Forschungszentrum Juelich and the Institute of Molecular and Cellular Anatomy of RWTH Aachen University in Germany. Transportation and accommodation will be provided for all participants.