# Protein Interactions in Vitro and in Vivo

Workshop
21st June 2004 to 23rd June 2004

Organisers: Dr Richard Sear (Surrey), Dr Jonathan Doye, Dr Ard Louis and Dr Michele Vendruscolo (Cambridge)

Diagrams of proteins

On the left-hand side is a conventional diagram, as widely used in molecular biology, of adenylate kinase, where the chain of amino acids is drawn by loops, with cylinders for the alpha helices. On the right-hand side is a diagram of a simple, physicists's' model of a protein, where the protein is taken to be cubic and where the differences in binding strengths of the different faces are denoted by different colours.

## Workshop Theme

The purpose of this workshop is to bring together biologists and physicists working on protein-protein interactions, including aggregation and crystallisation.

Most of the dry mass of cells is protein, and proteins do most of the work' in cells. Understanding their function is therefore essential to understand cells. The function of globular proteins requires specific and often very strong interactions, e.g. for recognition, in a complex mixture of thousands of other proteins. The proteins must also fold, be soluble, and avoid binding to other proteins, DNA, etc.

The workshop will bring together scientists from the physical and biological sciences to study how this feat is accomplished. Topics will include protein crystallisation and aggregation, protein interaction networks, macromolecular crowding, and related issues.

It will include a poster session where participants may present and discuss their work with scientist from theoretical physicists to structural biologists.