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Protein folding kinetics: some new twists on the transition state idea

Presented by: 
K Dill [UCSF]
Date: 
Thursday 22nd January 2004 - 09:00 to 10:00
Venue: 
INI Seminar Room 1
Session Title: 
Towards a Predictive Biology
Abstract: 

Some proteins fold very rapidly and with single-exponential kinetics. Despite this simplicity, the underlying microscopic processes are heterogeneous. Different molecules fold along different micro-routes. The energy landscapes are funnel-shaped. What are the routes and the rate-limiting steps? We explore the folding process with master equations. We find that the bottlenecks are sometimes heterogeneous. The reason for the folding speed is that proteins can fold via "zipping": multiple small localized optimization steps, rather than a single global optimization.

Presentation Material: 
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons