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Sequence patterning in simple de novo proteins with tailored association behavior

Presented by: 
JL Harden [Johns Hopkins]
Date: 
Wednesday 23rd June 2004 - 09:00 to 10:00
Venue: 
INI Seminar Room 1
Session Title: 
Protein-Protein Interactions in Vitro and in Vivo
Abstract: 

Patterning of charged or hydrophobic residues in repetitive amino acid sequences is often associated with the formation of well-defined assemblies such as helix bundles and beta sheets. In recent years, de novo protein designs have extensively utilized such patterned motifs to construct minimalist sequences that fold or aggregate in a predetermined manner via the specific association of secondary structures. This talk will discuss examples of de novo designs based on associating amphiphilic secondary structures. In particular, we will focus on a series of modular de novo proteins that preferentially form homo- and hetero-trimeric assemblies. The stability of these assemblies and the secondary structure of the associating elements in various solution conditions will be presented and discussed in the context of opportunities for theoretical models of these simple systems

University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons