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Achieving specificity in regulated protein-protein interactions

Presented by: 
L Pearl [Institute of Cancer Research]
Date: 
Wednesday 23rd June 2004 - 11:15 to 12:15
Venue: 
INI Seminar Room 1
Session Title: 
Protein-Protein Interactions in Vitro and in Vivo
Abstract: 

The crowded environment of a cell presents an individual protein with a considerable evolutionary challenge if it is to achieve specific 'signal' interactions with authentic macromolecular partners and minimise non-specific 'noise'. Simply maximising the interaction energy of the specific complexes improves the signal-to-noise ratio, but at the price of reversibility. Proteins involved in regulated rather than constitutive complexes, must achieve specificity by more subtle mechanisms, which will be illustrated by examples of macromolecular complexes determined in our laboratory.

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Presentation Material: 
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons