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Workshop Programme

for period 20-24 July

The Cardiac Physiome: Multi-scale and Multi-physics Mathematical Modelling Applied to the Heart

20-24 July

Timetable

Monday 20 July
08:15-09:00 Registration CPP
09:00-09:15 Welcome - David Wallace CPP
09:15-10:00 Noble, D (Oxford) CPP
  The cardiac physiome: how it began and where should it go Sem 1
Chair: Mark Boyett
Session: Cellular and sub-cellular Modelling 1
10:00-10:45 Vaughan-Jones, R (Oxford) CPP
  Connexins, buffers and mitochondria: novel pH/Ca2+ regulators in heart Sem 1
10:45-11:00 Soeller, C (Auckland) CPP
  Quantitative fluorescence imaging with up to 30 nm resolution to provide 3D data for models of cardiac Ca2+ handling Sem 1
11:00-11:30 Coffee CPP
Session: Cellular and sub-cellular Modelling 2
11:30-11:45 Saucerman, J (Virginia) CPP
  Modeling ß1-adrenergic receptor blockers and polymorphisms in cardiac myocytes Sem 1
11:45-12:00 Crampin, E (Auckland) CPP
  Modelling Ca2+ and InsP3-dependent hypertrophic signalling pathways in the heart Sem 1
12:00-12:15 Jeneson, J (TU, Eindhoven) CPP
  Development and testing of Cardiac Physiome cell model parts in skeletal muscle Sem 1
12:15-12:30 Beard, D (Medical College of Wisconsin) CPP
  Clinically observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism Sem 1
12:30-13:30 Lunch at Wolfson Court CPP
Chair: Richard Clayton
Session: Modelling of Cardiac Activation 1
13:30-14:15 Garfinkel, A (UCLA) CPP
  Mathematical concepts of cardiac arrhythmias Sem 1
14:15-14:30 Bernus, O (Leeds) CPP
  Towards depth-resolved optical imaging of cardiac activity: insights from computational models Sem 1
14:30-14:45 Boyett, M (Manchester) CPP
  Development of a virtual heart - Part l Sem 1
14:45-15:00 Zhang, H (Manchester) CPP
  Development of a virtual heart - Part ll Sem 1
15:00-15:30 Tea CPP
Session: Modelling of Cardiac Activation 2
15:30-15:45 Panfilov, S (Utrecht) CPP
  Electrophysiological metric and geometry of the heart Sem 1
15:45-16:00 Cherry, E (Cornell) CPP
  Restitution curve splitting as a mechanism for the bifurcation to alternans Sem 1
16:00-16:15 Holm, D (Imperial College London) CPP
  Optimal paths in cardiology Sem 1
16:15-16:30 Sachse, F (Utah) CPP
  A novel approach to multidomain modeling of electrical conduction in cardiac tissue Sem 1
16:30-16:45 Plank, G (Medizinische Universität Graz) CPP
  Using multiscale in-silico models of the heart for optimisation of anti-arrhythmia therapies Sem 1
16:45-17:45 Welcome Wine Reception CPP
18:45-19:30 Dinner at Wolfson Court (Residents Only) CPP
Tuesday 21 July
Chair: Sarah Waters
Session: Vascular Fluid - Structure Interaction
09:15-10:00 Popel, A (Johns Hopkins) CPP
  Systems biology of angiogenesis in ischemic diseases Sem 1
10:00-10:15 Davies, PF (Pennsylvania ) CPP
  Haemodynamics and endothelial phenotype heterogeneity Sem 1
10:15-10:30 Pries, A (Freie, Berlin) CPP
  Modeling adaptive processes: vascular remodeling Sem 1
10:30-10:45 Secomb, T (Arizona) CPP
  Theoretical models for regulation of blood flow in the microcirculation Sem 1
10:45-11:00 Passerini, T (Emory) CPP
  3D/1D geometrical multiscale modeling of vascular networks Sem 1
11:00-11:30 Coffee CPP
Chair: Tim Pedley
Session: Posters 1
11:30-12:30 CPP
  Commented Poster Session 1 Sem 1
12:30-13:30 Lunch at Wolfson Court CPP
Chair: Peter Hunter
Session: Cardiac Electro-Mechanical Coupling
13:30-14:15 McCulloch, A (UC, San Diego) CPP
  Multi-scale modeling of cardiac excitation-contraction coupling in the normal and failing heart Sem 1
14:15-14:30 Tavener, S (Colorado State) CPP
  A posteriori error estimation and adaptivity for operator decomposition methods Sem 1
14:30-14:45 Nash, M (Auckland) CPP
  Re-entry and fibrillation in an electro-mechanical model of the human ventricles Sem 1
14:45-15:00 Kohl, P (Oxford) CPP
  An attempt for dialectics: what can we learn from interdigitating wet and dry research into structure and function underlying elec/mech activity of the heart Sem 1
15:00-15:30 Tea CPP
15:30-15:45 Commented Posters 1 CPP
15:45-16:00 Poster CPP
16:00-16:15 Poster CPP
16:15-16:30 Poster CPP
18:45-19:30 Dinner at Woflson Court (Residents Only) CPP
Wednesday 22 July
Chair: Sasha Panfilov
Session: Imaged guided Analysis of Cardiac Electrophysiology and Arrhythmias
09:15-10:00 Trayanova, N (Johns Hopkins) CPP
  Integrative models of heart function in health and disease Sem 1
10:00-10:15 Rodriguez, B (Oxford) CPP
  Investigating drug-induced effects on cardiac electrophysiological function: from ion channels to the ECG Sem 1
10:15-10:30 Efimov, I (Washington, St. Louis) CPP
  Physiology of the human heart: Do we really know it? Sem 1
10:30-10:45 Fenton, F (Cornell ) CPP
  Termination of atrial fibrillation using pulsed low-energy far-field stimulation; a computational and optical mapping study Sem 1
10:45-11:00 Grau, V (Oxford) CPP
  Building detailed cardiac electrophysiological models from high-resolution images Sem 1
11:00-11:30 Coffee CPP
Chair: Jos Spaan
Session: Posters 1
11:30-12:30 CPP
  Commented Poster Session 2 Sem 1
12:30-13:30 Lunch at Wolfson Court CPP
Chair: Gunnar Seemann
Session: Three Dimensional Fluid Structure Interaction
13:30-13:45 Hose, R (Sheffield) CPP
  Fluid solid interaction for vascular applications Sem 1
13:45-14:00 Sherwin, S (Imperial College London) CPP
  Computational modelling to investigate the role of aging and species on arterial branch lesion patterns Sem 1
14:00-14:15 Salama, G (University of Pittsburgh) CPP
  Ion Channel Regulation by Estrogen Sem 1
14:15-14:30 Griffith, B (New York) CPP
  Simulating cardiac fluid-structure interaction using the immersed boundary method Sem 1
Chair: Gunner Seemann
14:30-14:45 Luo, X (Glasgow) CPP
  Dynamic modelling of chorded mitral valve Sem 1
14:45-15:00 Alber, M (North Dame) CPP
  Study of blood flow impact on growth of blood clot using a multi-scale model Sem 1
15:00-15:30 Tea CPP
15:30-15:45 Commented Posters CPP
15:45-16:00 Poster CPP
16:15-16:30 Poster CPP
18:45-19:30 Dinner at Wolfson Court (Residents Only) CPP
Thursday 23 July
Chair: Igor Efimov
Session: Imaged Based Modelling
09:30-10:15 Ayache, N (INRIA) CPP
  Towards personalization of cardiac models from medical images and signals Sem 1
10:15-10:30 Frangi, A (Pompeu Fabra ) CPP
  Overview of statistical shape models for cardiac image analysis and modeling Sem 1
10:30-10:45 LeGrice, I (Auckland) CPP
  Multi-scale volume imaging in animal models of disease Sem 1
10:45-11:00 Smaill, B (Auckland) CPP
  Tissue-specific models of electrical activity in the heart: Multi-scale and Multi-dimensional approaches Sem 1
11:00-11:30 Coffee CPP
Session: Imaged Based Modelling 2
11:30-11:45 Young, A (Auckland) CPP
  The Cardiac Atlas Project, Progress Report July 2009 Sem 1
11:45-12:00 Spaan, JAE (Academic Medical Center Amsterdam) CPP
  Intramural structure of coronary arteries and transmural distribution of coronary blood flow Sem 1
12:00-12:15 Shi, PC (RIT) CPP
  Integrative System Framework for Noninvasive Understanding of Myocardial Tissue Electrophysiology Sem 1
12:30-13:30 Lunch at Wolfson Court CPP
Chair: Nic Smith
Session: Human Translation
13:30-14:15 Razavi, R (King's College London) CPP
  Translating biophysical models to the heart of the clinic Sem 1
14:15-14:30 Kilner, P (Imperial College London) CPP
  The Whole Heart Sem 1
14:30-14:45 Weber, F (Karlsruhe (TH)) CPP
  Towards patient-specific simulations of atrial fibrillation Sem 1
14:45-15:00 Delingette, H (INRIA) CPP
  tba Sem 1
15:00-15:15 Rhode, K (King's College London) CPP
  Image and physiological data fusion for cardiac biophysical modelling Sem 1
15:15-15:45 Tea CPP
Session: Human Translation 2
15:45-16:00 Sermesant, M CPP
  Personalised electromechanical model of the heart for the prediction of the acute effects of cardiac resynchronisation therapy Sem 1
16:00-16:15 Seemann, G (Karlsruhe (TH)) CPP
  Modeling of cardiac Ischemia in human myocytes and tissue including spatiotemporal electrophysiological variations Sem 1
16:15-16:30 Bovendeerd, P (TU, Eindhoven) CPP
  Modeling cardiac growth and remodeling Sem 1
19:00-23:00 Conference Dinner at Emmanuel College CPP
Friday 24 July
Chair: David Paterson
Session: Physiome
09:30-10:15 Bassingthwaighte, J (Washington) CPP
  Integrative multilevel modular approach to modeling the cardiac physiome Sem 1
10:15-10:30 Jensen, O (Nottingham) CPP
  Building tissue mechanics into novel types of multi-scale models Sem 1
10:30-10:45 Omholt, S (Norwegian Uni of Life Sciences) CPP
  Genetics meets multiscale modeling: the epistemic value of causally cohesive genotype-phenotype (cGP) models Sem 1
10:45-11:00 Nielsen, P (Auckland) CPP
  CellML language and tools supporting the cardiac physiome CMS Mtg Rm 2
11:00-11:30 Coffee CPP
Chair: Closing lecture
11:30-11:45 Hunter, P (Auckland) CPP
  The cardiac physiome: next steps Sem 1
11:45-12:00 Smith, N (Oxford) CPP
  Closing comments Sem 1
12:30-13:30 Lunch at Wolfson Court CPP
18:45-19:30 Dinner at Wolfson Court (Residents Only) CPP
Other Seminars
Seminars in the University
National and International Scientific Research Meetings

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