| Monday 15 August |
| 08:00-08:55 |
Registration |
DAE |
| 08:55-09:00 |
Welcome from John Toland (INI Director Designate) |
DAE |
| Chair: Stefanie Biedermann |
| Session: Opening session |
| 09:00-09:45 |
Fedorov, V (GSK) |
DAE |
| |
Design of clinical trials with multiple end points of different types | Sem 1 |
| 09:45-10:30 |
Grieve, A (AptivSolutions) |
DAE |
| |
The Role of Operating Characteristic in Assessing Bayesian Designs in Pharmaceutical Drug Development | Sem 1 |
| 10:30-11:00 |
Morning coffee |
DAE |
| 11:00-11:45 |
Berry, D (MD Anderson Cancer Center) |
DAE |
| |
The Critical Path: "Biomarker Development and Streamlining Clinical Trials" | Sem 1 |
| 11:45-12:30 |
Atkinson, A |
DAE |
| |
Experiments for Enzyme Kinetic Models | Sem 1 |
| 12:30-13:30 |
Lunch at Wolfson Court |
DAE |
| Chair: Peter Mueller |
| Session: Treatment individualization |
| 14:00-14:45 |
Lee, J (MD Anderson Cancer Center) |
DAE |
| |
Biomarker-based Bayesian Adaptive Designs for Targeted Agent Development - Implementation and Lessons Learned from the BATTLE Trial | Sem 2 |
| Chair: Sandra Eldridge |
| Session: Cluster randomized trials |
| 14:00-14:45 |
Donner, A (Western Ontario) |
DAE |
| |
The Role of Cluster Randomization Trials in Health Research | Sem 1 |
| 14:45-15:25 |
Campbell, M (Sheffield) |
DAE |
| |
Cluster Randomised Trials: coping with selective recruitment, baseline covariates and anticipated drop-outs? | Sem 1 |
| Chair: Peter Mueller |
| Session: Treatment individualization |
| 14:45-15:25 |
Wathen, K (Johnson & Johnson) |
DAE |
| |
ISPY-2: Adaptive Design to Identify Treatments for Biomarker | Sem 2 |
| 15:25-16:05 |
Braun, T (Michigan) |
DAE |
| |
Bayesian Adaptive Designs for Identifying Maximum Tolerated Combinations of Two Agents
| Sem 2 |
| Chair: Sandra Eldridge |
| Session: Cluster randomized trials |
| 15:25-16:05 |
Eldridge, S (QMUL) |
DAE |
| |
Sample size calculations for cluster randomised trials | Sem 1 |
| 16:05-16:35 |
Afternoon tea in main building |
DAE |
| 16:35-17:15 |
White, I (MRC) |
DAE |
| |
A cluster-randomised cross-over trial | Sem 1 |
| Chair: Peter Mueller |
| Session: Early phase model-based design |
| 16:35-17:15 |
Bogachka, B (QMUL) |
DAE |
| |
Dose Selection Incorporating PK/PD Information in Early Phase Clinical Trials. | Sem 2 |
| 17:15-17:55 |
Cheung, K (Columbia) |
DAE |
| |
Objective Calibration of the Bayesian Continual Reassessment Method
| Sem 2 |
| Chair: Sandra Eldridge |
| Session: Cluster randomized trials |
| 17:15-17:55 |
Weijer, C (Western Ontario) |
DAE |
| |
Ethical issues posed by cluster randomized trials in health research | Sem 1 |
| 18:15-19:00 |
Dinner at Murray Edwards College (residents only) |
DAE |
| 19:00-19:45 |
Welcome wine reception and posters |
DAE |
| Tuesday 16 August |
| Chair: Vlad Dragalin |
| Session: Dose ranging: Methodology |
| 09:30-10:00 |
Dragalin, V (Aptiv Solutions, USA) |
DAE |
| |
Adaptive Dose-Ranging Designs with Two Efficacy Endpoints | Sem 1 |
| Chair: Vlad Dragalin |
| 10:00-10:30 |
Pronzato, L (CNRS) |
DAE |
| |
Penalized optimal design for dose finding | Sem 1 |
| 10:30-11:00 |
Jennison, C (Bath) |
DAE |
| |
Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach | Sem 1 |
| 11:00-11:30 |
Morning coffee |
DAE |
| 11:00-12:30 |
DAE informal discussion |
DAE |
| 11:30-12:00 |
Wang, S-J (FDA) |
DAE |
| |
Utility and pitfals of dose ranging trials with multiple study objectives: fixed or adaptive | Sem 1 |
| Session: Dose ranging: Industry challenges |
| 12:00-12:30 |
Pinheiro, J (Johnson & Johnson) |
DAE |
| |
Improving dose-finding methods in clinical development: design, adaptation, and modeling | Sem 1 |
| 12:30-13:30 |
Lunch at Wolfson Court |
DAE |
| 14:00-14:30 |
Bretz, F (Novartis) |
DAE |
| |
Response-adaptive dose-finding under model uncertainty | Sem 1 |
| Chair: Vlad Dragalin |
| Session: Dose ranging: Applications |
| 14:30-15:00 |
Thygesen, H (Lancaster) |
DAE |
| |
Dose Escalation using a Bayesian Model: rational decision rules. | Sem 1 |
| 15:00-15:30 |
Neuenschwander, B (Novartis Pharma AG) |
DAE |
| |
Bayesian approaches to Phase I clinical trials: methodological and practical aspects | Sem 1 |
| 15:30-16:00 |
Leonov, S (GlaxoSmithKline) |
DAE |
| |
Application of model-based designs in drug development | Sem 1 |
| 16:00-16:45 |
Afternoon tea |
DAE |
| Session: Panel Discussion |
| 16:45-18:00 |
Krams, M (Johnson & Johnson) |
DAE |
| |
Design of Experiments in Healthcare, dose-ranging studies, astrophysics and other dangerous things | Sem 1 |
| 18:15-19:00 |
Dinner at Murray Edwards College (residents only) |
DAE |
| Wednesday 17 August |
| Chair: Heiko Grossmann |
| Session: Choice Experiments: Theory & Background |
| 09:00-09:45 |
Louviere, J (U of Technology, Sydney) |
DAE |
| |
A Brief History of DCEs and Several Important Challenge | Sem 1 |
| 09:45-10:30 |
Ryan, M (Aberdeen) |
DAE |
| |
Discrete Choice Experiments in Health Economics | Sem 1 |
| 10:30-11:00 |
Morning coffee |
DAE |
| Session: Choice experiments: Experimental designs |
| 11:00-11:45 |
Rose, J (U of Technology, Sydney) |
DAE |
| |
Sample size, statistical power and discrete choice experiments: How much is enough | Sem 1 |
| Chair: Sandra Eldridge |
| Session: Stepped Wedge Designs |
| 11:00-11:45 |
Taylor, C (Birmingham) |
DAE |
| |
Systematic review of the use of stepped wedge cluster randomized trials | Sem 2 |
| Chair: Heiko Grossmann |
| Session: Choice experiments: Experimental designs |
| 11:45-12:30 |
Goos, P (Antwerpen) |
DAE |
| |
Optimal designs for discrete choice experiments in the presence of many attributes | Sem 1 |
| Chair: Sandra Eldridge |
| Session: Stepped Wedge Designs |
| 11:45-12:30 |
Moulton, L (Johns Hopkins) |
DAE |
| |
Challenges in the Design and Analysis of a Randomized, Phased Implementation (Stepped-Wedge) Study in Brazil | Sem 2 |
| Chair: Heiko Grossmann |
| Session: Choice experiments: Experimental designs |
| 12:30-13:00 |
Grossmann, H (QMUL) |
DAE |
| |
Partial profile paired comparison designs for avoiding information overload
| Sem 1 |
| Chair: Sandra Eldridge |
| Session: Stepped Wedge Designs |
| 12:30-13:00 |
Thompson, SG (Cambridge) |
DAE |
| |
Stepped wedge randomised trials | Sem 2 |
| 13:00-14:00 |
Lunch at Wolfson Court |
DAE |
| 14:00-17:00 |
Excursion: walk to Grantchester Orchard Tea Garden |
DAE |
| 19:30-22:30 |
Hog Roast Garden Party at The Moller Centre |
DAE |
