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Workshop Programme

for period 15-19 August

Design of Experiments in Healthcare

15-19 August

Timetable

Monday 15 August
08:00-08:55 Registration DAE
08:55-09:00 Welcome from John Toland (INI Director Designate) DAE
Chair: Stefanie Biedermann
Session: Opening session
09:00-09:45 Fedorov, V (GSK) DAE
  Design of clinical trials with multiple end points of different types Sem 1
09:45-10:30 Grieve, A (AptivSolutions) DAE
  The Role of Operating Characteristic in Assessing Bayesian Designs in Pharmaceutical Drug Development Sem 1
10:30-11:00 Morning coffee DAE
11:00-11:45 Berry, D (MD Anderson Cancer Center) DAE
  The Critical Path: "Biomarker Development and Streamlining Clinical Trials" Sem 1
11:45-12:30 Atkinson, A DAE
  Experiments for Enzyme Kinetic Models Sem 1
12:30-13:30 Lunch at Wolfson Court DAE
Chair: Peter Mueller
Session: Treatment individualization
14:00-14:45 Lee, J (MD Anderson Cancer Center) DAE
  Biomarker-based Bayesian Adaptive Designs for Targeted Agent Development - Implementation and Lessons Learned from the BATTLE Trial Sem 2
Chair: Sandra Eldridge
Session: Cluster randomized trials
14:00-14:45 Donner, A (Western Ontario) DAE
  The Role of Cluster Randomization Trials in Health Research Sem 1
14:45-15:25 Campbell, M (Sheffield) DAE
  Cluster Randomised Trials: coping with selective recruitment, baseline covariates and anticipated drop-outs? Sem 1
Chair: Peter Mueller
Session: Treatment individualization
14:45-15:25 Wathen, K (Johnson & Johnson) DAE
  ISPY-2: Adaptive Design to Identify Treatments for Biomarker Sem 2
15:25-16:05 Braun, T (Michigan) DAE
  Bayesian Adaptive Designs for Identifying Maximum Tolerated Combinations of Two Agents Sem 2
Chair: Sandra Eldridge
Session: Cluster randomized trials
15:25-16:05 Eldridge, S (QMUL) DAE
  Sample size calculations for cluster randomised trials Sem 1
16:05-16:35 Afternoon tea in main building DAE
16:35-17:15 White, I (MRC) DAE
  A cluster-randomised cross-over trial Sem 1
Chair: Peter Mueller
Session: Early phase model-based design
16:35-17:15 Bogachka, B (QMUL) DAE
  Dose Selection Incorporating PK/PD Information in Early Phase Clinical Trials. Sem 2
17:15-17:55 Cheung, K (Columbia) DAE
  Objective Calibration of the Bayesian Continual Reassessment Method Sem 2
Chair: Sandra Eldridge
Session: Cluster randomized trials
17:15-17:55 Weijer, C (Western Ontario) DAE
  Ethical issues posed by cluster randomized trials in health research Sem 1
18:15-19:00 Dinner at Murray Edwards College (residents only) DAE
19:00-19:45 Welcome wine reception and posters DAE
Tuesday 16 August
Chair: Vlad Dragalin
Session: Dose ranging: Methodology
09:30-10:00 Dragalin, V (Aptiv Solutions, USA) DAE
  Adaptive Dose-Ranging Designs with Two Efficacy Endpoints Sem 1
Chair: Vlad Dragalin
10:00-10:30 Pronzato, L (CNRS) DAE
  Penalized optimal design for dose finding Sem 1
10:30-11:00 Jennison, C (Bath) DAE
  Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach Sem 1
11:00-11:30 Morning coffee DAE
11:00-12:30 DAE informal discussion DAE
11:30-12:00 Wang, S-J (FDA) DAE
  Utility and pitfals of dose ranging trials with multiple study objectives: fixed or adaptive Sem 1
Session: Dose ranging: Industry challenges
12:00-12:30 Pinheiro, J (Johnson & Johnson) DAE
  Improving dose-finding methods in clinical development: design, adaptation, and modeling Sem 1
12:30-13:30 Lunch at Wolfson Court DAE
14:00-14:30 Bretz, F (Novartis) DAE
  Response-adaptive dose-finding under model uncertainty Sem 1
Chair: Vlad Dragalin
Session: Dose ranging: Applications
14:30-15:00 Thygesen, H (Lancaster) DAE
  Dose Escalation using a Bayesian Model: rational decision rules. Sem 1
15:00-15:30 Neuenschwander, B (Novartis Pharma AG) DAE
  Bayesian approaches to Phase I clinical trials: methodological and practical aspects Sem 1
15:30-16:00 Leonov, S (GlaxoSmithKline) DAE
  Application of model-based designs in drug development Sem 1
16:00-16:45 Afternoon tea DAE
Session: Panel Discussion
16:45-18:00 Krams, M (Johnson & Johnson) DAE
  Design of Experiments in Healthcare, dose-ranging studies, astrophysics and other dangerous things Sem 1
18:15-19:00 Dinner at Murray Edwards College (residents only) DAE
Wednesday 17 August
Chair: Heiko Grossmann
Session: Choice Experiments: Theory & Background
09:00-09:45 Louviere, J (U of Technology, Sydney) DAE
  A Brief History of DCEs and Several Important Challenge Sem 1
09:45-10:30 Ryan, M (Aberdeen) DAE
  Discrete Choice Experiments in Health Economics Sem 1
10:30-11:00 Morning coffee DAE
Session: Choice experiments: Experimental designs
11:00-11:45 Rose, J (U of Technology, Sydney) DAE
  Sample size, statistical power and discrete choice experiments: How much is enough Sem 1
Chair: Sandra Eldridge
Session: Stepped Wedge Designs
11:00-11:45 Taylor, C (Birmingham) DAE
  Systematic review of the use of stepped wedge cluster randomized trials Sem 2
Chair: Heiko Grossmann
Session: Choice experiments: Experimental designs
11:45-12:30 Goos, P (Antwerpen) DAE
  Optimal designs for discrete choice experiments in the presence of many attributes Sem 1
Chair: Sandra Eldridge
Session: Stepped Wedge Designs
11:45-12:30 Moulton, L (Johns Hopkins) DAE
  Challenges in the Design and Analysis of a Randomized, Phased Implementation (Stepped-Wedge) Study in Brazil Sem 2
Chair: Heiko Grossmann
Session: Choice experiments: Experimental designs
12:30-13:00 Grossmann, H (QMUL) DAE
  Partial profile paired comparison designs for avoiding information overload Sem 1
Chair: Sandra Eldridge
Session: Stepped Wedge Designs
12:30-13:00 Thompson, SG (Cambridge) DAE
  Stepped wedge randomised trials Sem 2
13:00-14:00 Lunch at Wolfson Court DAE
14:00-17:00 Excursion: walk to Grantchester Orchard Tea Garden DAE
19:30-22:30 Hog Roast Garden Party at The Moller Centre DAE
Thursday 18 August
Chair: Heiko Grossmann
Session: Choice Experiments: Applications
09:00-09:45 Lancsar, E (Monash) DAE
  Discrete choice experimental design for alternative specific choice models: an application exploring preferences for drinking water Sem 1
09:45-10:30 Kessels, R (Universiteit Antwerpen) DAE
  The usefulness of Bayesian optimal designs for discrete choice experiments Sem 1
10:30-11:00 Morning coffee DAE
Chair: Stefanie Biedermann
Session: Designs for drug development and noninferiority trials
11:45-12:30 van de Ven, P (Vrije U, Amsterdam) DAE
  An efficient alternative to the complete matched-pairs design for assessing non-inferiority of a new diagnostic test Sem 1
12:30-13:30 Lunch at Wolfson Court DAE
Chair: Peter Mueller
Session: Covariate adaptive designs
14:00-14:45 Ji, Y (.D. Anderson Cancer Center) DAE
  From Bench to Bedside: The Application of Differential Protein Networks on Bayesian Adaptive Designs for Trials with Targetted Therapies Sem 1
14:45-15:30 Kim, K (Wisconsin) DAE
  A Bayesian Adaptive Design with Biomarkers for Targeted Therapies and Some Commentary on Adaptive Designs Sem 1
15:30-16:00 Afternoon tea DAE
16:00-16:45 Thall, P (M.D. Anderson Cancer Center) DAE
  Optimizing the Concentration and Bolus of a Drug Delivered by Continuous Infusion Sem 1
16:45-17:30 Mukherjee, B (Michigan) DAE
  Discussion of three talks on (covariate) adaptive designs Sem 1
18:15-19:00 Dinner at Murray Edwards College (residents only) DAE
Friday 19 August
Chair: Peter Mueller
Session: Sequential and other Bayesian design
09:45-10:30 Bornkamp, B (Novartis) DAE
  Functional uniform prior distributions for nonlinear regression Sem 1
10:30-11:00 Morning coffee DAE
Chair: Peter Mueller
11:00-11:45 Savelieva Praz, M (Novartis) DAE
  PKPD modelling to optimize dose-escalation trials in Oncology Sem 1
11:45-12:30 Taylor, J (Michigan) DAE
  Designs and models for Phase I oncology trials with intra-patient dose escalation Sem 1
12:30-13:30 Lunch at Wolfson Court DAE
Chair: Stefanie Biedermann
Session: Clinical trial design
14:00-14:45 Flournoy, N (Missouri) DAE
  Some Issues Response-Adaptive Designs for Dose-finding Experiments Sem 1
14:45-15:30 Rosenberger, B (George Mason) DAE
  Principles for Response-Adaptive Randomization Sem 1
15:30-16:15 Giovagnoli, A (Bologna) DAE
  Recent developments in adaptive clinical trials to account for individual and collective ethics Sem 1
16:15-16:20 Closing remarks DAE
18:15-19:00 Dinner at Murray Edwards College (residents only) DAE
Other Seminars
Seminars in the University
National and International Scientific Research Meetings

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