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DAE

Seminar

Approximation of the individual Fisher information matrix and its use in design of population PK/PD studies

Leonov, S (Vertex)
Friday 12 August 2011, 09:45-10:30

Seminar Room 1, Newton Institute

Abstract

We continue a discussion started at PODE 2010 meeting about different types of approximation of the individual Fisher information matrix and their use in design of population PK/PD studies which are described by nonlinear mixed effects models. We focus on several Monte Carlo-based options and provide examples of their performance.

Presentation

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