Skip to content



An adaptive optimal design for the Emax model and its application in clinical trials

Leonov, S (GlaxoSmithKline)
Thursday 14 August 2008, 16:00-16:30

Seminar Room 1, Newton Institute


We discuss an adaptive design for a first-time-in-human dose-escalation study in patients. A project team working on a compound wished to maximize the efficiency of the study by using doses targeted at maximizing information about the dose-response relationship within certain safety constraints. We have developed an adaptive optimal design tool to recommend doses when the response follows an Emax model, with functionality for pre-trial simulation and in-stream analysis. We describe the methodology based on model-based optimal design techniques and present the results of simulations to investigate the operating characteristics of the applied algorithm.




The video for this talk should appear here if JavaScript is enabled.
If it doesn't, something may have gone wrong with our embedded player.
We'll get it fixed as soon as possible.

Back to top ∧