22 March - 26 March 2010
Isaac Newton Institute for Mathematical Sciences, Cambridge, UK
Workshop Organisers: Takis Konstantopoulos (Heriot-Watt) and Kavita Ramanan (Brown University).
Bruce Hajek (University of Illinois), Frank Kelly (Cambridge), P.R. Kumar (University of Illinois), Tom Kurtz (University of Wisconsin-Madison), Jean Mairesse (LIAFA), Philippe Robert (INRIA), John Tsitsiklis (MIT) and Ruth Williams (University of California, San Diego)
in association with the Newton Institute programmeStochastic Processes in Communication Sciences (11 January to 2 July 2010) Participants | Application | Accommodation and Cost
Title: A stochastic model of coupled enzymatic degradation
Joint work with Natalie Cookson, Jeff Hasty, Will Mather, Octavio Mondragon-Palomino and Lev Tsimring
A major challenge for systems biology is to deduce the molecular interactions that underly correlations observed between concentrations of different intracellular molecules. While direct explanations such as coupled transcription/translation or direct protein-protein interactions are often considered, potential indirect sources of coupling have received much less attention. In this talk, I will report on an investigation involving both theory and experiment of how correlations can arise generically from a post-translational coupling mechanism involving the processing of multiple protein species by a common enzyme.