An Isaac Newton Institute Focus Workshop

Protein Folding

Monday 15 March - Friday 19 March 2004

in association with the Newton Institute programme entitled Statistical Mechanics of Molecular and Cellular Biological Systems

This purpose of this week is to provide opportunity to discuss future directions of this rapidly-moving field. It is a workshop rather than a conference, so more people will be participating in the chaired and informal discussions than will speak, though the discussions will be introduced by presentations that review our present position and expose areas of ignorance. As it will be embedded in the longer Newton Institute Programme, other biophysicists and mathematicians in related areas will be able to participate as well as the folding community itself.

Programme

Provisional Programme:
Monday 15 March
12:30 13:30
Lunch
14:00 14:15
Introduction
14:15 15:00
A Fersht: Realistic and predictive simulation?
15:00 16:00
Discussion - Chair: T McLeish
16:00 16:30
Tea
16:30 17:30
Resumed plenary or informal discussions

Tuesday 16 March
09:00 10:00
T McLeish & D Wales: Features of high dimensional searches
10:00 11:00
Discussion - Chair: H Roder
11:00 11:30
Coffee
11:30 12:30
Resumed plenary or informal discussions
12:30 13:30
Lunch
14:00 15:00
E Shakhnovich & D Thirumalai: Course-grained view of transition state ensembles
15:00 16:00
Discussion - Chair: A Finkelstein
16:00 16:30
Tea
16:30 17:30
Resumed plenary or informal discussions

Wednesday 17 March
09:00 10:00
M Vendruscolo & E Paci: Fine-grained simulation of transition state ensembles
10:00 11:00
Discussion - Chair: TBA
11:00 11:30
Coffee
11:30 12:30
Resumed plenary or informal discussions
12:30 13:30
Lunch
14:00 15:00
J Fernandez & P Williams: Mechanical folding and unfolding
15:00 16:00
Discussion - Chair: J Clark
16:00 16:30
Tea
16:30 17:30
Resumed plenary or informal discussions

Thursday 18 March
09:00 10:00
M Oliveberg & S Radford: Dynamics of energy landscapes
10:00 11:00
Discussion - Chair: JE Shea
11:00 11:30
Coffee
11:30 12:30
Resumed plenary or informal discussions
12:30 13:30
Lunch
14:00 15:00
T Kiefhaber & W Eaton: Early events in protein folding
15:00 16:00
Discussion - Chair: A Fersht
16:00 16:30
Tea
16:30 17:30
Resumed plenary or informal discussions
19:30
Pre-dinner drinks Old Music Room, St John's College and Conference Dinner Wordsworth Room, St John's College

Friday 19 March
09:00 10:00
C Dobson: Review and summing-up
10:00 11:00
Discussion - Chair: SE Radford
11:00 11:30
Coffee

Scientific enquiries may be addressed to Tom McLeish (e-mail: TCBMcLeish@aol.com)

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