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Positron Emission Tomography Imaging in the Pharmaceutical Industry

Guo, Q (Imanova)
Wednesday 27 March 2013, 12:00-12:30

Seminar Room 1, Newton Institute


Human in vivo molecular imaging with positron emission tomography (PET) enables a new kind of 'precision pharmacology', able to address questions central to drug development. Biodistribution studies with drug molecules carrying positron-emitting radioisotopes can test whether a new chemical entity reaches a target tissue compartment (such as the brain) in sufficient amounts to be pharmacologically active. Competition studies, using a radioligand that binds to the target of therapeutic interest with adequate specificity, enable direct assessment of the relationship between drug plasma concentration and target occupancy. Quantitative mathematical techniques run through the whole process, from optimizing adaptive study designs, through image reconstruction, image registration, image segmentation, tracer kinetic analysis, probe development, PK/PD analyses and statistical analysis. We illustrate the application of mathematics to this area of imaging science by focusing on how bio-mathematical techniques can help predict, from in silico and in vitro data, which molecules will possess the right characteristics to produce a signal once labeled and injected into man.


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