How to untie it-translocation of a knotted protein through a pore
Szymczak, P (University of Warsaw, Poland)
Tuesday 04 September 2012, 11:50-12:10
Seminar Room 1, Newton Institute
Abstract
Proteins need to be unfolded when translocated through the pores in
mitochondrial and other cellular membranes. Knotted proteins, however,
might get stuck during this process since the diameter of the
pore is smaller than the size of maximally tightened knot. We report
the result of computer simulations of knotted protein translocation,
which show how the protein can avoid the topological traps and untie
its knot during the translocation
