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Locating knots and slipknots in open and closed macromolecules

Millett, K (University of California, Santa Barbara, USA)
Tuesday 04 September 2012, 16:20-17:00

Seminar Room 1, Newton Institute


Once it was imagined that proteins could be knotted, it was necessary to find procedures to identify the presence and precise location of knots and, later, slipknots in both open and closed macromolecules. While some of the initially proposed strategies were largely effective they often depended upon choices that gave rise to problems. In addition to a review of the historical development of these methods, we will review methods developed in collaboration with Akos Dobay, Andrzej Stasiak, Ben Sheldon and, later, with Rawdon in connection with work with Joanna Sułkowska and Jose Onuchic on protein structures. The relationship of this approach with that of other contemporay researcher will be described.

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