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Modeling CD8 Memory

Presented by: 
RN Antia [Emory]
Date: 
Monday 10th December 2001 - 16:00 to 17:00
Venue: 
INI Seminar Room 1
Session Title: 
Immunology, Ecology and Epidemiology (main themes)
Abstract: 
The generation and maintenance of immunological memory is a central problem in immunology. In this talk we address the following aspects of this problem focusing on CD8 responses.
1. Generation of memory: Recent experimental results show that brief stimulation with antigen is sufficient to cause antigen-specific CD8 cells to undergo sustained proliferation followed by differentiation into memory cells. We use simple mathematical models determine the characteristics of both the antigen-dependent and the antigen-independent components of the response in order that they are consistent with existing data on the dynamics of CD8 responses.

2. The memory phase: We use simple models to show how the longevity of immune memory depends critically on the mechanism for maintenance of homeostasis of CD8 cell populations. We We examine the dynamics of protection following re-stimulation with pathogens. Specifically we determine the regulation of secondary responses and the conditions under which memory is sufficient to give rise to protection.

University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons