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Inequalitites during life and death of T cells

Date: 
Wednesday 12th December 2001 - 16:00 to 17:00
Venue: 
INI Seminar Room 1
Session Title: 
Immunology, Ecology and Epidemiology (main themes)
Abstract: 
T cell selection during an immune response is being increasing observed with modern techniques, eg the (specific) T cell receptor (TCR) chain useage and its diversity alters throughout an immune response, and TCR avidity for the agonist ligands undergoes distinct focusing from a primary to secondary response. We explore physiologically structured models of T cell growth and T cell death to explain these observations. We demonstrate that significant selection of T cells can occur through heterogeneous expression of cytokine receptors and competition for growth/survival cytokines.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons