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Optimising the effectiveness of T cell activation

Date: 
Thursday 13th December 2001 - 16:00 to 17:00
Venue: 
INI Seminar Room 1
Session Title: 
Immunology, Ecology and Epidemiology (main themes)
Abstract: 
We will discuss the role of negative selection, MHC and presentation selectivity in optimising the effectiveness of T cell activation. We will show how this leads to MHC restriction and specific presentation strategies as well as upper and lower bounds on the number of MHC isoforms. We will also discuss the relation between negative selection and the need for peripheral tolerance mechanisms by analysing the effectiveness of negative selection as a function of the statistical structure of antigen presentation in terms of ubiquity and presentation propensity.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons