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Inference of cis and trans regulatory variation in the human genome

Presented by: 
M Dermitzakis [Wellcome Trust, Sanger Institute]
Date: 
Tuesday 12th December 2006 - 14:00 to 15:00
Venue: 
Center for Mathematical Sciences
Abstract: 

The recent comparative analysis of the human genome has revealed a large number of conserved non-coding sequences in mammalian genomes. However, our understanding of the function of non-coding DNA is very limited. In this talk I will present recent analysis in my group and collaborators that aims at the identification of functionally variable regulatory regions in the human genome by correlating SNPs and copy number variants with gene expression data. I will also be presenting some analysis on inference of trans regulatory interactions and evolutionary consequences of gene expression variation.

University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons