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Population genomics of human gene expression

Tuesday 1st April 2008 - 15:30 to 16:30
INI Seminar Room 1

The recent comparative analysis of the human genome has revealed a large fraction of functionally constrained non-coding DNA in mammalian genomes. However, our understanding of the function of non-coding DNA is very limited. In this talk I will present recent analysis in my group and collaborators that aims at the identification of functionally variable regulatory regions in the human genome by correlating SNPs and copy number variants with gene expression data. I will also be presenting some analysis on inference of trans regulatory interactions and evolutionary consequences of gene expression variation.

University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons