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Restitution curve splitting as a mechanism for the bifurcation to alternans

Monday 20th July 2009 - 15:45 to 16:00
INI Seminar Room 1
Session Title: 
Modelling of Cardiac Activation 2
Session Chair: 
Richard Clayton
Cardiac tissue displays a bifurcation in electrical response at rapid pacing rates. Traditionally, this bifurcation has been explained in terms of the slope of the restitution curve, a function that relates the response duration to the duration of the interval preceding it. However, we have recently observed that this curve is not a single-valued function under a wide range of physiological conditions. We will show examples of this restitution curve splitting and discuss the implications.

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Presentation Material: 
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons