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Investigating drug-induced effects on cardiac electrophysiological function: from ion channels to the ECG

Presented by: 
B Rodriguez [Oxford]
Date: 
Wednesday 22nd July 2009 - 10:00 to 10:15
Venue: 
INI Seminar Room 1
Session Title: 
Imaged guided Analysis of Cardiac Electrophysiology and Arrhythmias
Session Chair: 
Sasha Panfilov
Abstract: 
Many drugs fail to reach the market due to adverse side effects on the heart, and this translates into important socio-economic costs. A major concern for society, regulatory agencies and industry is that drug-induced alterations in cardiac function can increase the risk of development of potentially life threatening arrhythmias, such as Torsades de Pointes. Given the limitations of in vitro and in vivo testing in preclinical prediction of drug cardiotoxicity, there is increasing interest in in silico methods to supplement experimental methods. This presentation will describe how advanced computational techniques are developed and used in our group to investigate the mechanisms of drug action on cardiac electrophysiological function, from the ionic to the ECG level. Our main aim is to unravel the mechanisms of drug-induced arrhythmic risk in the context of high inter-subject electrophysiological variability, and to propose novel arrhythmic risk biomarkers based on this research.
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Presentation Material: 
University of Cambridge Research Councils UK
    Clay Mathematics Institute The Leverhulme Trust London Mathematical Society Microsoft Research NM Rothschild and Sons