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Optimal design of clinical trials in Alzheimer's disease

Presented by: 
S Ueckert [Uppsala]
Wednesday 10th August 2011 - 11:00 to 11:45
INI Seminar Room 1
Session Chair: 
D. Woods
Clinical trials in Alzheimer's disease are long, costly and have a low success rate. In this setting, optimal design theory constitutes a valuable tool to help planning of clinical studies efficiently. Our work presents how the theory of optimal design can be applied to a complex situation like an Alzheimer's trial. We illustrate how to handle challenges like dropout, covariate relationships and clinically relevant constraints. Furthermore, we illustrate how clinical trials can be directly optimized for drug effect detection power.
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons