skip to content
 

Optimal design of clinical trials in Alzheimer's disease

Presented by: 
S Ueckert [Uppsala]
Date: 
Wednesday 10th August 2011 - 11:00 to 11:45
Venue: 
INI Seminar Room 1
Session Chair: 
D. Woods
Abstract: 
Clinical trials in Alzheimer's disease are long, costly and have a low success rate. In this setting, optimal design theory constitutes a valuable tool to help planning of clinical studies efficiently. Our work presents how the theory of optimal design can be applied to a complex situation like an Alzheimer's trial. We illustrate how to handle challenges like dropout, covariate relationships and clinically relevant constraints. Furthermore, we illustrate how clinical trials can be directly optimized for drug effect detection power.
The video for this talk should appear here if JavaScript is enabled.
If it doesn't, something may have gone wrong with our embedded player.
We'll get it fixed as soon as possible.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons