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Approximation of the individual Fisher information matrix and its use in design of population PK/PD studies

Presented by: 
S Leonov [Vertex]
Date: 
Friday 12th August 2011 - 09:45 to 10:30
Venue: 
INI Seminar Room 1
Session Title: 
Population Optimum Design of Experiments
Session Chair: 
B. Bogacka
Abstract: 
We continue a discussion started at PODE 2010 meeting about different types of approximation of the individual Fisher information matrix and their use in design of population PK/PD studies which are described by nonlinear mixed effects models. We focus on several Monte Carlo-based options and provide examples of their performance.
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Presentation Material: 
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons