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Likelihood Maximization on Phylogenic Trees

Presented by: 
R Hauser University of Oxford
Date: 
Friday 19th July 2013 - 10:00 to 10:30
Venue: 
INI Seminar Room 1
Abstract: 
The problem of inferring the phylogenic tree of $n$ extant species from their genome is treated via mainly two approaches, the maximum parsimony and the maximum likelihood approach. While the latter is thought to produce more meaningful results, it is harder to solve computationally. We show that under a molecular clock assumption, the maximum likelihood model has a natural formulation that can be approached via branch-and-bound and polynomial optimization. Using this approach, we produce a counterexample to a conjecture relating to the reconstruction of an ancestral genome under the maximum parsimony and maximum likelihood approaches.
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Presentation Material: 
University of Cambridge Research Councils UK
    Clay Mathematics Institute The Leverhulme Trust London Mathematical Society Microsoft Research NM Rothschild and Sons