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Plenary Lecture 6: Resolving microbial community structure and function using next generation sequencing

Date: 
Tuesday 28th October 2014 - 14:00 to 15:00
Venue: 
INI Seminar Room 1
Abstract: 
Co-authors: Dr Konstantinos Gerasimidis (University of Glasgow), Dr Nick Loman (University of Birmingham)

I will give an overview of bioinformatics for analysing microbial communities using next generation sequence data. Determination of community structure from 16S rRNA gene sequencing and potential function from shotgun metagenomics data will be covered. There will be an emphasis on the relative merits of different techniques and analysis strategies. To illustrate these methods an example analysis from a longitudinal study of changes in the gut microbiome of children with Crohn's disease undergoing treatment with a therapeutic diet (exclusive enteral nutrition) will be presented.

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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons