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Optimal metabolic dynamics resolved by cyclic FBA

Date: 
Tuesday 4th November 2014 - 13:30 to 13:45
Venue: 
INI Seminar Room 1
Abstract: 
Co-authors: Willi Gottstein (Humboldt University Berlin, Institute of Theoretical Biology, Germany), Rainer Machne (Charité Universitätsmedizin Berlin, Institute of Theoretical Biology, Berlin, Germany), Ralf Steuer (Humboldt University Berlin, Institute of Theoretical Biology, Germany), Douglas Murray (Keio University, Institute for Advanced Biosciences, Japan)

We present a new variant of Flux Balance Analysis (FBA) that allows for dynamic modelling of metabolic cycles. In contrast to traditional dynamic FBA, which performs a series of simulations, discrete time frames are optimized simultaneously. The network is expanded to represent all species in every time frame and time transition fluxes are added to allow an exchange of metabolites between adjacent time frames. The steady state condition only holds true for the total process, and storage or depletion of metabolites throughout the cycle can be predicted. We apply this method to respiration cycles of continous yeast cultures to evaluate preferences of metabolic syntheses towards different energetic cellular states.

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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons