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Plenary Lecture 9: Computation and Polymer Synthesis for Designer Quorum Sensing Behaviour

Presented by: 
N Krasnogor Newcastle University
Thursday 27th November 2014 - 11:55 to 12:30
INI Seminar Room 1
Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one method by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. A combination of polymer and analytical chemistry, biological assays and computational modelling has been used to characterize the feedback between bacteria clustering and quorum sensing signalling. We have also derived design principles and chemical strategies for controlling bacterial behaviour at the population level. In this talk I will summarise our work on the utilisation of computational modelling for the design of synthetic polymers affecting QS phenotypes and, , time permitting, the combinatorial DNA library design tool (DNALD).
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons