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Optimal design and parameter estimation for population PK/PD models

Presented by: 
S Leonov & T Mielke ICON Clinical Research
Date: 
Tuesday 7th July 2015 - 10:30 to 11:00
Venue: 
INI Seminar Room 1
Abstract: 
In this presentation we discuss methods of model-based optimal experimental design that are used in population pharmacokinetic/pharmacodynamic studies and focus on links between various parameter estimation methods for nonlinear mixed effects models and various options for approximation of the information matrix in optimal design algorithms.
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Presentation Material: 
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons