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Model based adaptive optimal designs of adult to children bridging studies using FDA proposed stopping criteria

Date: 
Tuesday 7th July 2015 - 16:00 to 16:30
Venue: 
INI Seminar Room 1
Abstract: 
In this work we apply the FDA proposed precision criteria necessary for pediatric pharmacokinetic studies (Wang et. al., 2012) as a stopping criteria for a model based adaptive optimal design (MBAOD) of an adult to children pharmacokinetic bridging study. We demonstrate the power of the MBAOD compared to both traditional designs as well as non-adaptive optimal designs.
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Presentation Material: 
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons