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Designs for dose-escalation trials

Date: 
Wednesday 8th July 2015 - 12:00 to 12:30
Venue: 
INI Seminar Room 1
Abstract: 
For First-in-Human trials of a new drug, healthy volunteers are recruited in cohorts. For safety reasons, only the lowest dose and placebo may be used in the first cohort, and no new planned dose may be used until the one immediately below has been used in a previous cohort. How should doses be allocated to cohorts?
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Presentation Material: 
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons