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Osmosis, Electrophysiology and Cell Movement

Presented by: 
Yoichiro Mori University of Minnesota
Date: 
Thursday 16th July 2015 -
10:45 to 12:00
Venue: 
INI Seminar Room 1
Abstract: 
Water movement in the biological tissue is controlled primarily by osmosis, and the primary osmolytes are ions (Na, K, Cl etc). It is then natural to think that electrophysiology is in some way related to cell movement. This indeed seems to be the case; there is mounting evidence that ion channels and aquaporins play an important role in cell movement. In this talk, we will first review some classical facts about electrophysiology, focusing on its role in cell volume control. We will also discuss the classical subject of fluid secretion/absorption in epithelial systems, and compare this with recent work on a mode of cell movement that seems to be predominantly osmotic. We will then present a mathematical framework that couples electrophysiology, osmosis and cell mechanics in a natural way that allows for the study of this interplay. We will show preliminary 2D computational results of a deforming model cell moving using osmotic forces.
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons