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Epithelial intermediate filament organisation: Modes of regulation in vitro and in vivo

Presented by: 
Rudolf Leube RWTH Aachen University
Date: 
Monday 14th September 2015 - 11:30 to 12:30
Venue: 
INI Seminar Room 1
Abstract: 
The keratin intermediate filament cytoskeleton is a hallmark feature of epithelial cells. Molecular diversity is the basis of its finely tuned contribution to epithelial mechanics and function. Time-lapse analysis has revealed an unexpected degree of continuous re-structuring of the keratin scaffold in cultured epithelial cells. Multiple factors including other cytoskeletal filaments, cell adhesion sites and growth factors regulate keratin dynamics in vitro. The mechanisms governing the cell type-specific organisation of the keratin network in living organisms is much less understood. Yet, the polarized distribution of intermediate filaments in simple, one-layered epithelia is conserved from the nematode Caenorhabditis elegans to mammals. The use of recently established fluorescent reporter strains now allows monitoring and elucidating intermediate filament morphogenesis in vital tissues and organisms.
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons