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The Filament Based Lamellipodium Model: a continuum model derived from actin filament dynamics

Presented by: 
Christian Schmeiser Universität Wien
Date: 
Monday 14th September 2015 - 13:30 to 14:15
Venue: 
INI Seminar Room 1
Abstract: 
Co-authors: Angelika Manhart (Univ. of Vienna), Dietmar Oelz (New York Univ.), Nikolaos Sfakianakis (Univ. Mainz), J. Vic Small (Inst. f. Molecular Biotechn. Austria)

The lamellipodium is a flat cell protrusion functioning as a motility organelle for cells on flat substrates. It is a very dynamic structure mainly consisting of a network of filaments of polymerized actin. The Filament Based Lamellipodium Model is a two-dimensional, two-phase, anisotropic continuum model for the dynamics of this network, which has been developed over the past 8 years. It has been derived from a microscopic description based on the dynamics and interaction of individual filaments. Some aspects of the derivation of the model, of its analysis, and of its numerical solution will be presented, together with some recent simulation results.

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