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Cancer Cell Migration in 3D

Presented by: 
Denis Wirtz Johns Hopkins University
Tuesday 15th September 2015 - 09:00 to 10:00
INI Seminar Room 1
Two-dimensional (2D) in vitro culture systems have for a number of years provided a controlled and versatile environment for mechanistic studies of cell adhesion, polarization, and migration, three interrelated cell functions critical to cancer metastasis.  However, the organization and functions of focal adhesion proteins, protrusion machinery, and microtubule-based polarization in cells embedded in physiologically more relevant 3D extracellular matrices is qualitatively different from their organization and functions on conventional 2D planar substrates. This talk will describe the implications of the dependence of cell migratory patterns, protrusion generation, force generation, and cell mechanics on 3D settings.
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons