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DTI-Based Multiscale Modelling of Glioma

Presented by: 
Alexander Hunt Technische Universität Kaiserslautern
Tuesday 8th December 2015 - 13:30 to 14:15
INI Seminar Room 1
Co-Authors: C. Surulescu (TU Kaiserslautern), C. Engwer (WWU Munster)

Glioma invasion is a multiscale process ranging from subcellular biolo- gical events to the growth of a solid tumour mass. Key features involved in this process are migration and proliferation. The former is modelled using kinetic transport equations including medical data, which reveal the brain structure in detail. For characterising proliferation we use two alternative approaches: one relying on the go-or-growth dichotomy and involving two tumour cell populations, and the other paying attention to cell-tissue interactions seen as the onset of the biological processes leading to cell division.

For the biomedical application it is interesting to also include some therapy approach. We propose a new model combining receptor binding inhibition with radiation therapy and perform numerical simulations for the di
erent settings.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons