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Identifying sources of variation in biochemical networks

Presented by: 
Peter Swain
Date: 
Tuesday 19th January 2016 - 15:30 to 16:15
Venue: 
INI Seminar Room 1
Abstract: 
Co-authors: Clive Bowsher (), Margaritis Voliotis (University of Bristol)

To understand how cells control and exploit biochemical fluctuations, we must identify the sources of stochasticity, quantify their effects, and distinguish informative variation from confounding "noise". I will present an analysis that allows fluctuations of biochemical networks to be decomposed into multiple components, gives conditions for the design of experimental reporters to measure all components, and provides a technique to predict the magnitude of these components from models. Further, I will identify a particular component of variation that can be used to quantify the efficacy of information flow through a biochemical network. 
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons