skip to content

Exploiting single-cell fluctuations

Presented by: 
Johan Paulsson
Wednesday 20th January 2016 - 09:00 to 09:45
INI Seminar Room 1
All intracellular processes involve components present in low numbers, creating spontaneous fluctuations that in turn can enslave the components present in high numbers. The mechanisms often appear complex, with reaction rates that depend nonlinearly on concentrations, indirect feedback loops, and distributed delays. Most systems are also sparsely characterized, with a few steps known in detail but many important interactions not even identified. In the first half of the talk, I will discuss mathematical approaches that exploit natural fluctuations to more reliably analyze data and to make predictions about what complex biological networks cannot do. In the second half I will discuss some of our recent experimental results on the role of fluctuations in cells, e.g. in the segregation of mitochondria, oscillations of synthetic genetic networks, bacterial cell fate decisions, and DNA repair.
The video for this talk should appear here if JavaScript is enabled.
If it doesn't, something may have gone wrong with our embedded player.
We'll get it fixed as soon as possible.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons