Presented by:
Johan Paulsson
Date:
Wednesday 20th January 2016 - 09:00 to 09:45
Venue:
INI Seminar Room 1
Event:
Abstract:
All intracellular processes involve components present in
low numbers, creating spontaneous fluctuations that in turn can enslave the
components present in high numbers. The mechanisms often appear complex, with
reaction rates that depend nonlinearly on concentrations, indirect feedback
loops, and distributed delays. Most systems are also sparsely characterized,
with a few steps known in detail but many important interactions not even
identified. In the first half of the talk, I will discuss mathematical
approaches that exploit natural fluctuations to more reliably analyze data and
to make predictions about what complex biological networks cannot do. In the
second half I will discuss some of our recent experimental results on the role
of fluctuations in cells, e.g. in the segregation of mitochondria, oscillations
of synthetic genetic networks, bacterial cell fate decisions, and DNA repair.
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