Presented by:
Pieter Rein ten Wolde
Date:
Thursday 7th April 2016 - 09:00 to 09:45
Venue:
INI Seminar Room 1
Abstract:
Gene expression is typically regulated by gene
regulatory proteins that bind to the DNA. Experiments have shown that these
proteins find their DNA target site via a combination of 3D diffusion in the
cytoplasm and 1D diffusion along the DNA. This stochastic transport sets a
fundamental limit on the precision of gene regulation. We derive this limit
analytically and show by particle-based GFRD simulations that our expression is
highly accurate under biologically relevant conditions.
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