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Fundamental limits to transcriptional regulatory control

Presented by: 
Pieter Rein ten Wolde
Date: 
Thursday 7th April 2016 - 09:00 to 09:45
Venue: 
INI Seminar Room 1
Abstract: 
Gene expression is typically regulated by gene regulatory proteins that bind to the DNA. Experiments have shown that these proteins find their DNA target site via a combination of 3D diffusion in the cytoplasm and 1D diffusion along the DNA. This stochastic transport sets a fundamental limit on the precision of gene regulation. We derive this limit analytically and show by particle-based GFRD simulations that our expression is highly accurate under biologically relevant conditions.
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons