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A stochastic story of two receptors and two ligands

Presented by: 
Carmen Molina-Paris University of Leeds
Date: 
Thursday 7th April 2016 - 14:00 to 14:45
Venue: 
INI Seminar Room 1
Abstract: 
In this talk, I will introduce the role of the co-receptors CD28 and CTLA-4 in the immune system. Both CD28 and CTLA-4 molecules are expressed on the membrane of T cells and can bind CD80 and CD86 ligand molecules, expressed on the membrane of antigen presenting cells. Classical immunology has identified CD28 co-receptor as enhancing the signal received by T cells from their T cell receptors (TCRs), and CTLA-4 as suppressing TCR signals. New experimental work is supporting a different role for the CTLA-4 molecule. In this talk, I will describe work in progress by our group, to model as  a multi-variate stochastic process the system of two receptors and two ligands. 
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons