Presented by:
Carmen Molina-Paris University of Leeds
Date:
Thursday 7th April 2016 - 14:00 to 14:45
Venue:
INI Seminar Room 1
Abstract:
In this talk, I will introduce the role of the
co-receptors
CD28 and CTLA-4 in the immune system. Both CD28 and
CTLA-4 molecules are expressed on the membrane of T cells and can bind CD80 and
CD86 ligand molecules, expressed on the membrane of
antigen presenting cells. Classical immunology has identified CD28 co-receptor
as enhancing the signal received by T cells from their T cell receptors (TCRs),
and CTLA-4 as suppressing TCR signals. New experimental work is supporting a
different role for the CTLA-4 molecule.
In this talk, I will describe work in progress by our
group, to model as a multi-variate
stochastic process the system of two receptors and two ligands.
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