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Modeling and stochastic analysis of autoregulation of the Krox20 transcription factor driving cellular diversification and hindbrain patterning

Presented by: 
Jürgen Reingruber CNRS - Ecole Normale Superieure Paris
Date: 
Tuesday 17th May 2016 - 15:00 to 16:00
Venue: 
INI Seminar Room 2
Abstract: 
I will present the molecular implementation and function of the autoregulatory loop that amplifies and maintains the expression of Krox20, a transcription factor governing vertebrate hindbrain segmentation. By combining data analysis, biophysical modeling, stochastic analysis and simulations, I dissect the autoregulation process as a function of an initiation signal that leads to promoter activation and subsequent mRNA and protein production. Autoregulation generates a bistable switch that turns a transient initiation signal into a persistent cell fate. The duration and strength of the input signal controls  patterning by modulating the distribution between the cell fates.
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons