skip to content

Modeling and stochastic analysis of autoregulation of the Krox20 transcription factor driving cellular diversification and hindbrain patterning

Presented by: 
Jürgen Reingruber CNRS - Ecole Normale Superieure Paris
Tuesday 17th May 2016 - 15:00 to 16:00
INI Seminar Room 2
I will present the molecular implementation and function of the autoregulatory loop that amplifies and maintains the expression of Krox20, a transcription factor governing vertebrate hindbrain segmentation. By combining data analysis, biophysical modeling, stochastic analysis and simulations, I dissect the autoregulation process as a function of an initiation signal that leads to promoter activation and subsequent mRNA and protein production. Autoregulation generates a bistable switch that turns a transient initiation signal into a persistent cell fate. The duration and strength of the input signal controls  patterning by modulating the distribution between the cell fates.
The video for this talk should appear here if JavaScript is enabled.
If it doesn't, something may have gone wrong with our embedded player.
We'll get it fixed as soon as possible.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons