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Models of Microtubule Acetylation

Presented by: 
Andrew Rutenberg Dalhousie University
Tuesday 21st June 2016 - 14:00 to 14:45
INI Seminar Room 1
Microtubule (MT) acetylation is done post-translationally in the MT lumen by the acetyltransferase alpha-TAT1. A simple picture is that alpha-TAT1 enters the lumen at the open ends of MT, and diffuses inside while acetylating. Complicating this picture, alpha-TAT1 is approximately half the luminal diameter --- indicating that it may undergo single-file diffusion (SFD). Computationally, we explore the consequences of SFD in this system. Experimentally, in collaboration with the group of Guillaume Montagnac (Institut Gustave Roussy), immunofluorescence techniques allows us to measure the acetylation pattern of individual MT. We try to reconcile the computational and experimental approaches, and highlight open questions. 
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons