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Spatial simulation and analysis of actin filament dynamics and wave propagation

Presented by: 
Kevin Sanft University of North Carolina
Date: 
Tuesday 21st June 2016 - 14:45 to 15:30
Venue: 
INI Seminar Room 1
Abstract: 
Co-authors: Hans Othmer (University of Minnesota), Yougan Cheng (University of Minnesota)

Actin filaments play an important role in many cellular processes, including cell motility. We present a stochastic model of actin filament dynamics in a three-dimensional Cartesian domain. Actin monomers bind to nucleation sites on the membrane and polymerize to form filaments (F-actin). F-actin polymers interact with membrane-bound nucleation promoting factors via a positive feedback loop. The resulting model produces waves of actin filaments that propagate along the membrane. Simulating polymer growth presents challenges to traditional Gillespie-type simulations. We describe a rule-based simulation approach to handle the many states of actin filament growth. Finally, we discuss techniques for managing the simulation output data.
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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons