skip to content

Spatial simulation and analysis of actin filament dynamics and wave propagation

Presented by: 
Kevin Sanft University of North Carolina
Tuesday 21st June 2016 - 14:45 to 15:30
INI Seminar Room 1
Co-authors: Hans Othmer (University of Minnesota), Yougan Cheng (University of Minnesota)

Actin filaments play an important role in many cellular processes, including cell motility. We present a stochastic model of actin filament dynamics in a three-dimensional Cartesian domain. Actin monomers bind to nucleation sites on the membrane and polymerize to form filaments (F-actin). F-actin polymers interact with membrane-bound nucleation promoting factors via a positive feedback loop. The resulting model produces waves of actin filaments that propagate along the membrane. Simulating polymer growth presents challenges to traditional Gillespie-type simulations. We describe a rule-based simulation approach to handle the many states of actin filament growth. Finally, we discuss techniques for managing the simulation output data.
The video for this talk should appear here if JavaScript is enabled.
If it doesn't, something may have gone wrong with our embedded player.
We'll get it fixed as soon as possible.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons