The cardiac physiome: multi-scale and multi-physics mathematical modelling applied to the heart

Workshop theme

Engineering and mathematical approaches coupled to physiology are not only advancing our understanding of cardiac function, but are on the threshold of clinical application for diagnosis and treatment of heart disease. Coupled with a dramatic increase in the quantity and quality of experimental data, these modelling developments now provide the potential for analyzing complex cause and effect relationships, and for improved mechanistic understanding in a range of physiological systems.

The scientific programme of this conference will focus on the combination of experimental and modelling research required for developing integrated multi-scale and multi-physics cardiac models. The program will be built around providing opportunities for (1) keynote presentations to propose issues and stimulate discussion; (2) opportunities for early career researchers to present their work and develop cross-disciplinary collaborations; and (3) focused group discussions on facilitating Physiome style research which exploits the full potential of a combined modelling and experimental approach. Throughout the week we will promote common themes and questions relevant to the contribution of mathematical and computational science to the cardiac Physiome endeavor as whole, specifically:

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How can model parameters be unambiguously linked to specific and consistent experimental data sets?
What is important for iterative testing and development of models, and what is needed to enable experimentally based researchers to use and directly interact with models?
How can we apply techniques and frameworks demonstrated in the heart to other physiological systems e.g. pancreas, lung, kidney, immune system?
How can model databases and ontologies support robust model testing and accelerate the iterative refinement within the research community?
How well can quantitative animal models be mapped across species to deduce clinical inference for human health?

Presentations and Abstract Submission

Keynote speakers include Nicholas Ayache (INRIA), Alan Garfinkel (UC, Los Angeles), Peter Hunter (Auckland), Andrew McCulloch (UC, San Diego), Denis Noble (Oxford), Sasha Popel (Johns Hopkins), Reza Rezavi (King's College London), Natalia Trayanova (Johns Hopkins) and Richard Vaughan-Jones (Oxford).

While a number of conference participants have been invited we also welcome applications from interested researchers, to attend and present their work.

We anticipate sessions to cover the following topics:

Multiple physiological scales: Sub-cellular, cellular, cell to cell communication, tissue structure and properties, whole heart structure and function, and human translation.
Multiple physics: Calcium and pH regulation, electrical excitation, mechanical contraction, electromechanical coupling, coronary blood flow and ventricular fluid dynamics.
Tools and infrastructure: Simulation, visualisation and databasing tools, image based modelling tools and other infrastructure needed for integrative work by the community as a whole.

We invite contributions in these areas for presentation as talks (12 minutes with 3 minutes for discussion), or as posters. The deadline for abstract submission is 13 March 2009.

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Applications for this workshop are now closed

Timetable

Monday 20th July 2009
08:15 to 09:00	Registration	Room 1
09:00 to 09:15	Welcome - David Wallace	Room 1
09:15 to 10:00	Denis Noble University of Oxford The cardiac physiome: how it began and where should it go	Room 1
10:00 to 10:45	Richard Vaughan-Jones University of Oxford Connexins, buffers and mitochondria: novel pH/Ca2+ regulators in heart	Room 1
10:45 to 11:00	Christian Soeller University of Auckland Quantitative fluorescence imaging with up to 30 nm resolution to provide 3D data for models of cardiac Ca2+ handling	Room 1
11:00 to 11:30	Coffee	No Room Required
11:30 to 11:45	Jeffrey Saucerman University of Virginia Modeling ß1-adrenergic receptor blockers and polymorphisms in cardiac myocytes	Room 1
11:45 to 12:00	Edmund Crampin University of Auckland Modelling Ca2+ and InsP3-dependent hypertrophic signalling pathways in the heart	Room 1
12:00 to 12:15	Jeroen Jeneson Technische Universität Eindhoven Development and testing of Cardiac Physiome cell model parts in skeletal muscle	Room 1
12:15 to 12:30	Daniel Andrew Beard Medical College of Wisconsin Clinically observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism	Room 1
12:30 to 13:30	Lunch at Wolfson Court	No Room Required
13:30 to 14:15	Alan Garfinkel University of California, Los Angeles Mathematical concepts of cardiac arrhythmias	Room 1
14:15 to 14:30	Olivier Bernus University of Leeds Towards depth-resolved optical imaging of cardiac activity: insights from computational models	Room 1
14:30 to 14:45	Mark Boyett University of Manchester Development of a virtual heart - Part l	Room 1
14:45 to 15:00	Henggui Zhang University of Manchester Development of a virtual heart - Part ll	Room 1
15:00 to 15:30	Tea	No Room Required
15:30 to 15:45	Alexander Panfilov Universiteit Utrecht Electrophysiological metric and geometry of the heart	Room 1
15:45 to 16:00	Elizabeth Maura Cherry Cornell University Restitution curve splitting as a mechanism for the bifurcation to alternans	Room 1
16:00 to 16:15	Optimal paths in cardiology	Room 1
16:15 to 16:30	Frank Sachse University of Utah A novel approach to multidomain modeling of electrical conduction in cardiac tissue	Room 1
16:30 to 16:45	Gernot Plank University of Oxford Using multiscale in-silico models of the heart for optimisation of anti-arrhythmia therapies	Room 1
16:45 to 17:45	Welcome Wine Reception	No Room Required
18:45 to 19:30	Dinner at Wolfson Court (Residents Only)	No Room Required

Tuesday 21st July 2009
09:15 to 10:00	Aleksander Popel Johns Hopkins University Systems biology of angiogenesis in ischemic diseases	Room 1
10:00 to 10:15	Peter Davies University of Pennsylvania Haemodynamics and endothelial phenotype heterogeneity	Room 1
10:15 to 10:30	Axel Pries Freie Universität Berlin Modeling adaptive processes: vascular remodeling	Room 1
10:30 to 10:45	Tim Secomb University of Arizona Theoretical models for regulation of blood flow in the microcirculation	Room 1
10:45 to 11:00	Tiziano Passerini Emory University 3D/1D geometrical multiscale modeling of vascular networks	Room 1
11:00 to 11:30	Coffee	No Room Required
11:30 to 12:30	Commented Poster Session 1	No Room Required
12:30 to 13:30	Lunch at Wolfson Court	No Room Required
13:30 to 14:15	Andrew McCulloch University of California, San Diego Multi-scale modeling of cardiac excitation-contraction coupling in the normal and failing heart	Room 1
14:15 to 14:30	Simon Tavener Colorado State University A posteriori error estimation and adaptivity for operator decomposition methods	Room 1
14:30 to 14:45	Martyn Nash University of Auckland Re-entry and fibrillation in an electro-mechanical model of the human ventricles	Room 1
14:45 to 15:00	Peter Kohl University of Oxford An attempt for dialectics: what can we learn from interdigitating wet and dry research into structure and function underlying elec/mech activity of the heart	Room 1
15:00 to 15:30	Tea	No Room Required
15:30 to 15:45	Commented Posters 1	No Room Required
15:45 to 16:00	Poster	No Room Required
16:00 to 16:15	Poster	No Room Required
16:15 to 16:30	Poster	No Room Required
18:45 to 19:30	Dinner at Woflson Court (Residents Only)	No Room Required

Wednesday 22nd July 2009
09:15 to 10:00	Natalia Trayanova Johns Hopkins University Integrative models of heart function in health and disease	Room 1
10:00 to 10:15	Blanca Rodriguez University of Oxford Investigating drug-induced effects on cardiac electrophysiological function: from ion channels to the ECG	Room 1
10:15 to 10:30	Igor Efimov Washington University in St. Louis Physiology of the human heart: Do we really know it?	Room 1
10:30 to 10:45	Flavio Fenton Cornell University Termination of atrial fibrillation using pulsed low-energy far-field stimulation; a computational and optical mapping study	Room 1
10:45 to 11:00	Vicente Grau University of Oxford Building detailed cardiac electrophysiological models from high-resolution images	Room 1
11:00 to 11:30	Coffee	No Room Required
11:30 to 12:30	Commented Poster Session 2	No Room Required
12:30 to 13:30	Lunch at Wolfson Court	No Room Required
13:30 to 13:45	Rod Hose University of Sheffield Fluid solid interaction for vascular applications	Room 1
13:45 to 14:00	Spencer Sherwin Imperial College London Computational modelling to investigate the role of aging and species on arterial branch lesion patterns	Room 1
14:00 to 14:15	Guy Salama University of Pittsburgh Ion Channel Regulation by Estrogen	Room 1
14:15 to 14:30	Boyce Griffith New York University Simulating cardiac fluid-structure interaction using the immersed boundary method	Room 1
14:30 to 14:45	Dynamic modelling of chorded mitral valve	Room 1
14:45 to 15:00	Mark Alber University of Notre Dame Study of blood flow impact on growth of blood clot using a multi-scale model	Room 1
15:00 to 15:30	Tea	No Room Required
15:30 to 15:45	Commented Posters	No Room Required
15:45 to 16:00	Poster	No Room Required
16:15 to 16:30	Poster	No Room Required
18:45 to 19:30	Dinner at Wolfson Court (Residents Only)	No Room Required

Thursday 23rd July 2009
09:30 to 10:15	Nicholas Ayache INRIA Sophia Antipolis Towards personalization of cardiac models from medical images and signals	Room 1
10:15 to 10:30	Alejandro Frangi Universitat Pompeu Fabra Overview of statistical shape models for cardiac image analysis and modeling	Room 1
10:30 to 10:45	Ian LeGrice University of Auckland Multi-scale volume imaging in animal models of disease	Room 1
10:45 to 11:00	Bruce Smaill University of Auckland Tissue-specific models of electrical activity in the heart: Multi-scale and Multi-dimensional approaches	Room 1
11:00 to 11:30	Coffee	Room 1
11:30 to 11:45	Alistair Young University of Auckland The Cardiac Atlas Project, Progress Report July 2009	Room 1
11:45 to 12:00	Jos Spaan Academic Medical Center Amsterdam Intramural structure of coronary arteries and transmural distribution of coronary blood flow	Room 1
12:00 to 12:15	Pengcheng Shi Rochester Institute of Technology Integrative System Framework for Noninvasive Understanding of Myocardial Tissue Electrophysiology	Room 1
12:30 to 13:30	Lunch at Wolfson Court	No Room Required
13:30 to 14:15	Reza Razavi King's College London Translating biophysical models to the heart of the clinic	Room 1
14:15 to 14:30	Philip Kilner Imperial College London The Whole Heart	Room 1
14:30 to 14:45	Frank Michael Weber Towards patient-specific simulations of atrial fibrillation	Room 1
14:45 to 15:00	Adaptive Tetrahedral Meshing for Personalized Cardiac Simulations	Room 1
15:00 to 15:15	Kawal Rhode King's College London Image and physiological data fusion for cardiac biophysical modelling	Room 1
15:15 to 15:45	Tea	No Room Required
15:45 to 16:00	Maxime Sermesant INRIA Sophia Antipolis Personalised electromechanical model of the heart for the prediction of the acute effects of cardiac resynchronisation therapy	Room 1
16:00 to 16:15	Gunnar Seemann Modeling of cardiac Ischemia in human myocytes and tissue including spatiotemporal electrophysiological variations	Room 1
16:15 to 16:30	Peter Bovendeerd Technische Universiteit Eindhoven Modeling cardiac growth and remodeling	Room 1
19:00 to 23:00	Conference Dinner at Emmanuel College	No Room Required

Friday 24th July 2009
09:30 to 10:15	James Bassingthwaighte University of Washington Integrative multilevel modular approach to modeling the cardiac physiome	Room 1
10:15 to 10:30	Building tissue mechanics into novel types of multi-scale models	Room 1
10:30 to 10:45	Stig Omholt Norwegian University of Life Sciences (UMB) Genetics meets multiscale modeling: the epistemic value of causally cohesive genotype-phenotype (cGP) models	Room 1
10:45 to 11:00	Poul Nielsen University of Auckland CellML language and tools supporting the cardiac physiome	Centre for Mathematical Sciences
11:00 to 11:30	Coffee	No Room Required
11:30 to 11:45	Peter Hunter University of Auckland The cardiac physiome: next steps	Room 1
11:45 to 12:00	Nic Smith University of Oxford Closing comments	Room 1
12:30 to 13:30	Lunch at Wolfson Court	No Room Required
18:45 to 19:30	Dinner at Wolfson Court (Residents Only)	No Room Required

The cardiac physiome: multi-scale and multi-physics mathematical modelling applied to the heart

Speakers

Mark Alber University of Notre Dame
Nicholas Ayache INRIA Sophia Antipolis
James Bassingthwaighte University of Washington
Daniel Andrew Beard Medical College of Wisconsin
Olivier Bernus University of Leeds
Peter Bovendeerd Technische Universiteit Eindhoven
Mark Boyett University of Manchester
Elizabeth Maura Cherry Cornell University
Edmund Crampin University of Auckland
Peter Davies University of Pennsylvania
Igor Efimov Washington University in St. Louis
Flavio Fenton Cornell University
Alejandro Frangi Universitat Pompeu Fabra
Alan Garfinkel University of California, Los Angeles
Vicente Grau University of Oxford
Boyce Griffith New York University
Rod Hose University of Sheffield
Peter Hunter University of Auckland
Jeroen Jeneson Technische Universität Eindhoven
Philip Kilner Imperial College London
Peter Kohl University of Oxford
Ian LeGrice University of Auckland
Andrew McCulloch University of California, San Diego
Martyn Nash University of Auckland
Poul Nielsen University of Auckland
Denis Noble University of Oxford
Stig Omholt Norwegian University of Life Sciences (UMB)
Alexander Panfilov Universiteit Utrecht
Tiziano Passerini Emory University
Gernot Plank University of Oxford
Aleksander Popel Johns Hopkins University
Axel Pries Freie Universität Berlin
Reza Razavi King's College London
Kawal Rhode King's College London
Blanca Rodriguez University of Oxford
Frank Sachse University of Utah
Guy Salama University of Pittsburgh
Jeffrey Saucerman University of Virginia
Tim Secomb University of Arizona
Gunnar Seemann
Maxime Sermesant INRIA Sophia Antipolis
Spencer Sherwin Imperial College London
Pengcheng Shi Rochester Institute of Technology
Bruce Smaill University of Auckland
Nic Smith University of Oxford
Christian Soeller University of Auckland
Jos Spaan Academic Medical Center Amsterdam
Simon Tavener Colorado State University
Natalia Trayanova Johns Hopkins University
Richard Vaughan-Jones University of Oxford
Frank Michael Weber
Alistair Young University of Auckland
Henggui Zhang University of Manchester

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