Design and analysis of experiments

Programme theme

Design of experiments was born as a result of an unlikely, but true anecdote: a lady claimed before R.A. Fisher that she was able to ascertain whether milk was poured before or after tea in her cuppa. Fisher devised a study to verify her claim and, in turn, this gave birth to Experimental Design. Agricultural experiments formed the core around which the theory evolved in its origins in the 1930s. The theory of Design of Experiments has since blossomed into many different approaches, ranging from optimal designs for dynamical models in pharmacokynetic studies, and designs for industrial experimentation, to designs of simulation experiments in climate change, to name but a few. The mathematical techniques currently used in different branches of Design are vast, for example Galois theory, non linear optimization, algebraic geometry and association schemes.

In this six-month programme we aim to bring together some of the world experts in Design of Experiments. An important objective of the programme is to bring people from different areas of design to talk to each other, and hopefully, work together. Another is to interact with other statisticians and researchers from other disciplines, to ensure that the topic remains relevant to novel areas of experimentation, and to communicate its importance.

Four workshops have been proposed for the programme, based around the following topics:

1 Accelerating industrial productivity via deterministic computer experiments and stochastic simulation experiments

2 Optimal designs for mixed effects models

3 Design of experiments in healthcare

4 Experiments for processes with time or space dynamics

In addition to the workshops, the DEMA (Designed experiments: recent advances in methods and applications) conference will also be held as part of the programme.

Click here to download the programme's final scientific report

Preprints

Title	Year	Programme
Pure Error REML for Analyzing Data from Split-Plot and Multi-Stratum Designs Authors: Steven Gilmour, Peter Goos, Heiko Grossmann Download PDF	2011	DAE	3 August 2017
Optimal discriminating designs for several competing regression models Authors: Holger Dette, D Braess Download PDF	2011	DAE	21 October 2016
Optimal designs for dose finding studies with an active control Authors: Christine Kiss, N Benda, Frank Bretz, Holger Dette Download PDF	2011	DAE	21 October 2016
T-optimal designs for discrimination between two polynomial models Authors: Slava Melas, P Shpilev, Holger Dette Download PDF	2011	DAE	21 October 2016
A procedure for finding an improved upper bound on the number of optimal design points Authors: Min Yang, Nancy Flournoy, SW Hyun Download PDF	2011	DAE	21 October 2016
The construction of optimal designs for dose-escalation studies Authors: AE Clark, Linda Haines Download PDF	2011	DAE	21 October 2016
Optimal experimental design for generalized regression models Authors: AM Herzberg, Anthony Atkinson, Val Fedorov, R Zhang Download PDF	2011	DAE	21 October 2016
Calibrated very robust regression Authors: Marco Riani, Anthony Atkinson, D Perrotta Download PDF	2011	DAE	21 October 2016
Optimal designs for contingent response models with application to toxicity-efficacy studies-a technical report Authors: Nancy Flournoy, H Rabie Download PDF	2011	DAE	21 October 2016
Two-stage sensitivity-based group screening in computer experiments Authors: Thomas Santner, Angela Dean, H Moon Download PDF	2011	DAE	21 October 2016
Non-collapsing space-filling designs for bounded non-rectangular regions Authors: Thomas Santner, Angela Dean, D Draguljic Download PDF	2011	DAE	21 October 2016
Multiobjective optimization of expensive black-box functions via expected maximin improvement Authors: Thomas Santner, JD Svenson Download PDF	2011	DAE	21 October 2016
Estimating sensitivity indices from computer simulator output Authors: Thomas Santner, Angela Dean, H Moon, J Svenson Download PDF	2011	DAE	21 October 2016
Design and analysis of experiments testing for biodiversity effects in ecology Authors: J Reiss, Rosemary Bailey Download PDF	2011	DAE	21 October 2016
Best intention designs in dose-finding studies Authors: Val Fedorov, Nancy Flournoy, R Zhang, Yuehui Wu Download PDF	2011	DAE	21 October 2016
Model selection and parameter estimation in non-linear nested models: a sequential generalized DKL-optimum design Authors: Caterina May, Chiara Tommasi Download PDF	2011	DAE	21 October 2016
Inference on a new sigmoid regression model with unknown support and unbounded likelihood function Authors: Nancy Flournoy, Haiying Wang Download PDF	2011	DAE	21 October 2016
Screening strategies in the presence of Interactions Authors: D Draguljic, DC Woods, Angela Dean, Susan Lewis, AE Vine Download PDF	2011	DAE	21 October 2016
Optimal blocked minimum-support designs for non-linear models Authors: Peter van de Ven, DC Woods Download PDF	2011	DAE	21 October 2016
Quasi-Latin designs and their use in glasshouse experiments Authors: Chris Brien, Rosemary Bailey, TT Tran, J Boland Download PDF	2011	DAE	21 October 2016
Optimal designs for the Michaelis Menten model with correlated observations Authors: Holger Dette, Joachim Kunert Download PDF	2011	DAE	21 October 2016
Optimal designs for rational regression models Authors: Holger Dette, Christine Kiss Download PDF	2011	DAE	21 October 2016
A graphical method for comparing response-adaptive randomization procedures Authors: Nancy Flournoy, Linda Haines, William Rosenberger Download PDF	2011	DAE	21 October 2016
Information in a two-stage adaptive optimal design Authors: Adam Lane, P Yao, Nancy Flournoy Download PDF	2011	DAE	21 October 2016
A note on robustness of D-optimal block designs for two-colour microarray experiments Authors: Rosemary Bailey, K Schiffl, Dieter Hilgers Download PDF	2011	DAE	21 October 2016
Split-plot type designs for physical prototype testing Authors: L Lee Ho, CA Vivacqua, AL Santos De Pinho Download PDF	2011	DAE	21 October 2016
Automating the analysis of variance of orthogonal designs Authors: Heiko Grossmann Download PDF	2011	DAE	21 October 2016
Optimal designs for the prediction of individual effects in random coefficient regression Authors: Maryna Prus, Rainer Schwabe Download PDF	2011	DAE	21 October 2016
Optimal design for count data with binary predictors in item response theory Authors: U Grasshoff, H Holling, Rainer Schwabe Download PDF	2011	DAE	21 October 2016
Testing for Lack of Fit in Blocked and Split-Plot Response Surface Designs Authors: Steven Gilmour, Peter Goos Download PDF	2011	DAE	21 October 2016
Optimal cross-over designs for full interaction models Authors: Rosemary Bailey, Pierre Druilhet Download PDF	2011	DAE	21 October 2016
Particle swarm optimization techniques for finding optimal mixture designs Authors: Haiying Wang, Ying Q Chen, C-C Huang, Weng-Kee Wong Download PDF	2011	DAE	21 October 2016
Using animal instincts to design efficient biomedical studies Authors: J Qiu, Ying Q Chen, Haiying Wang, Weng-Kee Wong Download PDF	2011	DAE	21 October 2016
Optimal Minimax Designs via Particle Swarm Optimization Methods Authors: Ying Q Chen, S-P Chang, Haiying Wang, H-C Tung, Weng-Kee Wong Download PDF	2011	DAE	21 October 2016
Confidence intervals for ratio of two Poisson rates using the method of variance estimates recovery Authors: William Li, Boxin Tang, Weng-Kee Wong Download PDF	2011	DAE	21 October 2016
A Semidefinite Programming based approach for finding Bayesian optimal designs for nonlinear models Authors: BPM Duarte, Weng-Kee Wong Download PDF	2011	DAE	21 October 2016
Computer experiment designs via particle swarm optimization Authors: Erin Leatherman, Angela Dean, Thomas Santner Download PDF	2011	DAE	21 October 2016
Designs for computer experiments that minimize the weighted integrated mean square prediction error Authors: Erin Leatherman, Angela Dean, Thomas Santner Download PDF	2011	DAE	21 October 2016
On optimality and construction of circular repeated-measurements designs Authors: Rosemary Bailey, Ewan Cameron, Katarzyna Filipiak, Joachim Kunert, Augustyn Markiewicz Download PDF	2011	DAE	21 October 2016
On the optimality of circular block designs under a mixed interference model Authors: Katarzyna Filipiak, Augustyn Markiewicz Download PDF	2011	DAE	21 October 2016
Automatic generation of generalised regular factorial designs Authors: A Kobilinsky, Hervé Monod, Rosemary Bailey Download PDF	2011	DAE	21 October 2016
A note on foldover of 2$^k$$^-$$^p$ designs with column permutations Authors: Dennis Lin, William Li Download PDF	2011	DAE	21 October 2016
Idle thoughts of a 'well-calibrated' Bayesian in clinical drug development Authors: Andy Grieve Download PDF	2011	DAE	21 October 2016
An algorithm for finding D-efficient equivalent-estimation second-order split-plot designs Authors: Peter Goos, Bradley Jones Download PDF	2011	DAE	21 October 2016
Penalized generalized least squares for model selection under restricted randomization Authors: Peter Goos, Kalliopi Mylona Download PDF	2011	DAE	21 October 2016
Benchmark testing of algorithms for very robust regression Authors: D Perrotta, Anthony Atkinson, Marco Riani, ET Al, F Torti Download PDF	2011	DAE	21 October 2016
Covariate-balanced response-adaptive designs for clinical trials with continuous responses that target allocation proportions Authors: A Biswas, Luc Pronzato, Anthony Atkinson Download PDF	2011	DAE	21 October 2016
Some recent developments in the design of adaptive clinical trials Authors: Alessandra Giovagnoli, M Zagoraiou, A Baldi Antognini Download PDF	2011	DAE	21 October 2016
Using graphs to find the best block designs Authors: Rosemary Bailey, Ewan Cameron Download PDF	2011	DAE	21 October 2016
Optimum designs for the equality of parameters in enzyme inhibition kinetic models Authors: Anthony Atkinson, Basia Bogacka Download PDF	2011	DAE	21 October 2016
Of copulas, quantiles, ranks and spectra an $L_1$-approach to spectral analysis Authors: M Hallin, T Kley, S Volgushev, Holger Dette Download PDF	2011	DAE	21 October 2016
Optimal design for linear models with correlated observations Authors: Andrey Pepelyshev, Anatoly Zhigljavsky, Holger Dette Download PDF	2011	DAE	21 October 2016
Zeros and ratio asymptotics for matrix orthogonal polynomials Authors: Holger Dette, S Delvaux Download PDF	2011	DAE	21 October 2016

Workshops

DAEW01

Seminars

Thursday 28th July 2011
14:00 to 16:00	Optimal resistor networks and their relevance to incomplete block designs	Room 2

Thursday 4th August 2011
10:00 to 12:00	Optimal designs and geometries	Room 2

Monday 8th August 2011
13:30 to 15:30	Informal Discussion	Room 2

Tuesday 16th August 2011
09:25 to 09:30	Welcome from Dragalin, V & INI Director Designate	Room 1

Monday 26th September 2011
09:00 to 17:00	Cambridge Statistics Initiative - poster sessions	Discussion Room
09:00 to 17:00	Cambridge Statistics Initiative meeting	Room 1
09:30 to 09:40	Cambridge Statistics Initiative (CSI) Special One-Day meeting: Introduction	Room 1
09:40 to 09:50	Measures for capturing coverage of genetic variation in a population	Room 1
09:50 to 10:00	Statistical modeling of gene expression levels	Room 1
10:00 to 10:10	Rare variant analysis in large-scale association and sequencing studies	Room 1
10:10 to 10:20	Estimating statistical significance of exome sequencing data for rare mendelian disorders using population-wide linkage analysis	Room 1
10:20 to 10:30	On the exploration of Affymetrix ligation-based SNP assays	Room 1
10:30 to 10:40	Inferring an individual's "physiological" age from multiple ageing-related phenotypes	Room 1
10:40 to 10:50	Bayesian evidence synthesis to estimate progression of human papillomavirus	Room 1
11:10 to 12:00	Coffee & Poster Session	Discussion Room
12:00 to 12:10	Inverse probability weighting with missing predictors of missingness or treatment assignment	Room 1
12:10 to 12:20	Log-concavity, nearest-neighbour classification, variable selection and the Statistics Clinic	Room 1
12:20 to 12:30	Functional Bernstein-type inequalities via Rademacher Processess; with applications to statistics	Room 1
12:30 to 12:40	Variation independent parametrizations	Room 1
12:40 to 12:50	Forward Smoothing and Online EM in changepoint systems	Room 1
14:00 to 14:10	Bayesian sequential experiment design for quantum tomography	Room 1
14:10 to 14:20	Rosemary Bailey Queen Mary University of London Design and analysis of biodiversity experiments	Room 1
14:20 to 14:30	Optimal design and analysis procedures in two stage trials with a binary endpoint	Room 1
14:30 to 14:40	Chris Brien University of South Australia Multiphase experiments in the biological sciences	Room 1
14:40 to 14:50	Casual inference in observational epidemiology: looking into mechanism	Room 1
14:50 to 15:00	Structural equation modeling analysis for causal inference from multiple omics datasets	Room 1
15:15 to 16:05	Coffee & Poster Session	Discussion Room
16:05 to 16:15	Identifying the effect of treatment on the treated	Room 1
16:15 to 16:25	Communicating and evaluating probabilities	Room 1
16:25 to 16:35	Statistical problems in computer vision	Room 1
16:35 to 16:45	Andrei Bejan University of Cambridge; The Smith Institute Using velocity fields in evaluating urban traffic congestion via sparse public transport data and crowedsourced maps	Room 1
16:45 to 16:55	Evaluating Peterborough's no cold calling initiative using space-time Bayesian hierarchical modelling	Room 1
17:10 to 17:30	Cambridge Statistics Initiative (CSI) Special One-Day meeting: Discussion & Conclusions	Room 1

Tuesday 11th October 2011
11:00 to 12:30	Hervé Monod INRA - Institut National de la Recherche Agronomique INRA: Generation of flexible regular fractional factorial designs and its implementation in R	Room 1

Thursday 13th October 2011
14:00 to 15:00	Heiko Grossmann Otto-von-Guericke-Universität Magdeburg Automatic analysis of variance for orthogonal plot structures	Room 1

Tuesday 25th October 2011
11:00 to 12:00	Pierre Druilhet Université Blaise Pascal Optimal cross-over designs for full interaction models	Room 1

Thursday 10th November 2011
17:00 to 18:00	Causal Inference from Experimental Data (30th R A Fisher Memorial Lecture)	Room 1

Thursday 24th November 2011
14:00 to 14:30	Adam Lane University of Missouri Information in Two Stage Adaptive Design	Room 1
14:30 to 15:00	KyungMann Kim University of Wisconsin-Madison Optimizing Combination Therapy under a Bivariate Weibull Distribution with Application to Toxicity and Efficacy Responses	Room 1

Monday 28th November 2011
14:00 to 15:00	Rosemary Bailey Queen Mary University of London Discussion	Discussion Room

Wednesday 30th November 2011
10:00 to 11:00	Registration and coffee	No Room Required
12:30 to 14:00	Lunch	No Room Required

Thursday 8th December 2011
14:00 to 15:00	Radoslav Harman Comenius University in Bratislava Multiplicative algorithms for computing D-optimal experimental designs with linear constraints on the design weights	Room 1

Monday 19th December 2011
14:00 to 15:00	Strategies to Analyse Unreplicated Factorial Split-Plot Designs	Room 1

Tuesday 20th December 2011
10:00 to 11:00	Jordan Ko Université Paris 7 - Denis-Diderot An introduction to polynomial chaos and its applications	Room 1

Monday 6th July 2015
09:00 to 09:45	Registration	No Room Required
09:45 to 10:00	Welcome by John Toland (INI Director) and Rosemary Bailey (St Andrews)	Room 1
10:00 to 10:45	Designing an adaptive trial with treatment selection and a survival endpoint	Room 1
10:45 to 11:15	Morning Coffee	No Room Required
11:15 to 12:00	Adaptive dose-finding with power control	Room 1
12:00 to 12:30	Start-up designs for response-adpative randomization procedures	Room 1
12:30 to 13:30	Lunch at Wolfson Court	No Room Required
13:30 to 14:15	An adaptive optimal design with a small fixed stage-one sample size	Room 1
14:15 to 15:00	Some critical issues in adaptive experimental designs for treatment comparisons	Room 1
15:00 to 15:30	Afternoon Tea	No Room Required
15:30 to 16:15	Adaptive population enrichment designs	Room 1
16:15 to 17:00	A population-finding design with non-parametric Bayesian response model	Room 1
17:00 to 18:00	Welcome Wine Reception	No Room Required

Tuesday 7th July 2015
09:00 to 17:30	Population Optimum Design of Experiments	No Room Required
09:30 to 10:00	Registration	No Room Required
10:00 to 10:05	Welcome	No Room Required
10:05 to 10:30	10 years of progress in population design methodology and applications	Room 1
10:30 to 11:00	Optimal design and parameter estimation for population PK/PD models	Room 1
11:00 to 11:30	Morning Coffee	No Room Required
11:30 to 12:00	Evaluation of the Fisher information matrix in nonlinear mixed effects models using Monte Carlo Markov Chains	Room 1
12:00 to 12:30	Computation of the Fisher information matrix for discrete nonlinear mixed effects models	Room 1
12:30 to 14:00	Sandwich lunch at INI	No Room Required
14:00 to 14:30	Designs for generalized linear models with random block effects	Room 1
14:30 to 15:00	Design and Analysis of In-Vitro Pharmacokinetic Experiments	Room 1
15:00 to 15:30	Incorporating pharmacokinetic information in phase I studies in small populations	Room 1
15:30 to 16:00	Afternoon Tea	No Room Required
16:00 to 16:30	Model based adaptive optimal designs of adult to children bridging studies using FDA proposed stopping criteria	Room 1
16:30 to 17:00	Cost constrained optimal designs for regression models with random parameters	Room 1
17:00 to 17:30	Discussion	Room 1

Wednesday 8th July 2015
09:00 to 09:40	Model-robust designs for quantile regression	Room 1
09:40 to 10:20	Locally optimal designs for errors-in-variables models	Room 1
10:20 to 11:00	Nature-inspired meta-heuristic algorithms for generating optimal experimental designs	Room 1
11:00 to 11:30	Morning Coffee	No Room Required
11:30 to 12:00	Construction of efficient experimental designs under resource constraints	Room 1
12:00 to 12:30	Designs for dose-escalation trials	Room 1
12:30 to 13:30	Lunch at Wolfson Court	No Room Required
13:30 to 15:00	Free time	No Room Required
14:45 to 15:15	Afternoon Tea	No Room Required
15:00 to 17:00	Poster session	No Room Required
19:30 to 22:00	Conference Dinner at Cambridge Union Society hosted by Cambridge Dining Co.	No Room Required

Thursday 9th July 2015
09:30 to 17:00	Open for Business - Design of Experiments in Drug Development	No Room Required

Friday 10th July 2015
09:00 to 09:45	Efficient study designs	Room 1
09:45 to 10:30	Cross-sectional versus longitudinal design: does it matter?	Room 1
10:30 to 11:00	Morning Coffee	No Room Required
11:00 to 11:45	Randomization for small clinical trials	Room 1
11:45 to 12:30	Assessment of randomization procedures based on single sequences under selection bias	Room 1
12:30 to 13:30	Lunch at Wolfson Court	No Room Required
13:30 to 14:15	Optimal designs for correlated observations	Room 1
14:15 to 15:00	Designs for dependent observations	Room 1
15:00 to 15:30	Afternoon Tea	No Room Required
15:30 to 16:15	Optimal crossover designs with interactions between treatments and experimental units	Room 1
16:15 to 17:00	On connections between orthogonal arrays and D-optimal designs for certain generalized linear models with group effects	Room 1

Organisers

Rosemary Bailey Queen Mary University of London
Stefanie Biedermann University of Southampton
Basia Bogacka Queen Mary University of London
Holgar Dette Ruhr-Universität Bochum
Peter Goos Universiteit Antwerpen
Andy Lynch University of Cambridge
Hugo Maruri-Aguilar Queen Mary University of London

Speakers

Rosemary Bailey Queen Mary University of London
Andrei Bejan University of Cambridge
Chris Brien University of South Australia
Pierre Druilhet Université Blaise Pascal
Heiko Grossmann Otto-von-Guericke-Universität Magdeburg
Radoslav Harman Comenius University in Bratislava
KyungMann Kim University of Wisconsin-Madison
Jordan Ko Université Paris 7 - Denis-Diderot
Adam Lane University of Missouri
Hervé Monod INRA - Institut National de la Recherche Agronomique

Programme theme

Preprints

Pure Error REML for Analyzing Data from Split-Plot and Multi-Stratum Designs

Optimal discriminating designs for several competing regression models

Optimal designs for dose finding studies with an active control

T-optimal designs for discrimination between two polynomial models

A procedure for finding an improved upper bound on the number of optimal design points

The construction of optimal designs for dose-escalation studies

Optimal experimental design for generalized regression models

Calibrated very robust regression

Optimal designs for contingent response models with application to toxicity-efficacy studies-a technical report

Two-stage sensitivity-based group screening in computer experiments

Non-collapsing space-filling designs for bounded non-rectangular regions

Multiobjective optimization of expensive black-box functions via expected maximin improvement

Estimating sensitivity indices from computer simulator output

Design and analysis of experiments testing for biodiversity effects in ecology

Best intention designs in dose-finding studies

Model selection and parameter estimation in non-linear nested models: a sequential generalized DKL-optimum design

Inference on a new sigmoid regression model with unknown support and unbounded likelihood function

Screening strategies in the presence of Interactions

Optimal blocked minimum-support designs for non-linear models

Quasi-Latin designs and their use in glasshouse experiments

Optimal designs for the Michaelis Menten model with correlated observations

Optimal designs for rational regression models

A graphical method for comparing response-adaptive randomization procedures

Information in a two-stage adaptive optimal design

A note on robustness of D-optimal block designs for two-colour microarray experiments

Split-plot type designs for physical prototype testing

Automating the analysis of variance of orthogonal designs

Optimal designs for the prediction of individual effects in random coefficient regression

Optimal design for count data with binary predictors in item response theory

Testing for Lack of Fit in Blocked and Split-Plot Response Surface Designs

Optimal cross-over designs for full interaction models

Particle swarm optimization techniques for finding optimal mixture designs

Using animal instincts to design efficient biomedical studies

Optimal Minimax Designs via Particle Swarm Optimization Methods

Confidence intervals for ratio of two Poisson rates using the method of variance estimates recovery

A Semidefinite Programming based approach for finding Bayesian optimal designs for nonlinear models

Computer experiment designs via particle swarm optimization

Designs for computer experiments that minimize the weighted integrated mean square prediction error

On optimality and construction of circular repeated-measurements designs

On the optimality of circular block designs under a mixed interference model

Automatic generation of generalised regular factorial designs

A note on foldover of 2$^k$$^-$$^p$ designs with column permutations

Idle thoughts of a 'well-calibrated' Bayesian in clinical drug development

An algorithm for finding D-efficient equivalent-estimation second-order split-plot designs

Penalized generalized least squares for model selection under restricted randomization

Benchmark testing of algorithms for very robust regression

Covariate-balanced response-adaptive designs for clinical trials with continuous responses that target allocation proportions

Some recent developments in the design of adaptive clinical trials

Using graphs to find the best block designs

Optimum designs for the equality of parameters in enzyme inhibition kinetic models

Of copulas, quantiles, ranks and spectra an $L_1$-approach to spectral analysis

Optimal design for linear models with correlated observations

Zeros and ratio asymptotics for matrix orthogonal polynomials

Workshops

Experiments for processes with time or space dynamics

Optimum design for mixed effects non-linear and generalised linear models

Design of experiments in healthcare

Designed experiments: recent advances in methods and applications: DEMA 2011

Accelerating industrial productivity via deterministic computer experiments & stochastic simulation

Algebraic method in experimental design

Seminars

Organisers

Speakers

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