Vertical integration in biology: from molecules to organisms

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Workshop theme

Biological systems exhibit prominent behaviour at the levels of both individuals and populations. Empirical and theoretical research at each of these levels has led to tremendous advances in knowledge; however, much less is understood about the mechanisms underlying the integration and coordination of behaviour at the individual level to produce coherent population-level behaviour (vertical integration). This workshop will bring together leading experimental and theoretical researchers, together with those working at the interface between the two communities. The aim will be to identify and explore new interdisciplinary approaches to the problem of vertical integration. Examples will be drawn from the broad areas of cell and developmental biology and physiology.

Specific areas of focus:

cell signalling
morphogenesis
gene networks
neural networks and neurophysiology
cardiology

The workshop will incorporate a special one-day workshop Gene Networks: Bridging the Gap Between Bioinformatics and Mathematical Modelling, to be held on Tuesday 25 September. Applications for this day alone will be considered.

Scientific enquiries may be addressed to Dr Nick Monk or Professor Philip Maini.

Timetable

Monday 24th September 2001
09:00 to 00:00	Registration at the Newton Institute	No Room Required
12:30 to 13:30	Lunch	No Room Required
13:30 to 13:40	Opening Remarks	Room 1
13:40 to 14:40	Modelling molecular events in a small volume of living cytoplasm	Room 1
14:40 to 15:40	Gabor Forgacs University of Missouri The role of the cytoskeleton in intracellular signalling	Room 1
15:40 to 16:10	Tea	No Room Required
16:10 to 17:10	GATA-3 transcriptional memory in T helper lymphocytes a mathematical model of steady-state and temporal behaviour	Room 1
17:10 to 18:10	Wine Reception	No Room Required
18:45 to 19:30	Dinner at Wolfson Court (residents only)	No Room Required

Tuesday 25th September 2001
08:30 to 09:15	Registration for Gene Networks Meeting At the Isaac Newton Institute	No Room Required
09:20 to 09:30	Opening Remarks Meeting room 2 at Centre for Mathematical Sciences	No Room Required
09:30 to 10:10	Hamid Bolouri University of Hertfordshire Reverse engineering of a developmental genetic regulatory network Meeting room 2 at the Centre for Mathematical Sciences	No Room Required
10:10 to 10:50	Looking at the future of functional genomics from inside the Drosophila blastoderm -(Meeting Rm 2 at the Centre for Math. Sciences)	No Room Required
10:50 to 11:10	Coffee At the Centre for Mathematical Sciences	No Room Required
11:10 to 11:50	George Von Dassow University of Washington Models of modules: putting the molecular parts together into genetic devices (Meeting rm 2 at the Centre for Mathematical Sciences)	No Room Required
11:50 to 12:30	Helen Causton MRC Clinical Sciences Centre Microarrays and yeast: insights into gene regulation Meeting room 2 at the Centre for Mathematical Sciences	No Room Required
12:30 to 13:30	Lunch At the Centre for Mathematical Sciences	No Room Required
13:50 to 14:00	Keith Vass University of Glasgow Normalisation and local variation in microarrays Meeting room 2 at Centre for Mathematical Sciences	No Room Required
14:00 to 14:40	Alvis Brazma Reconstructing elements of gene networks from genome scale microarray data (Meeting rm 2 at the Centre for Mathematical Sciences)	No Room Required
14:40 to 15:20	From gene expression to gene interaction Meeting room 2 at the Centre for Mathematical Sciences	No Room Required
15:20 to 15:40	Tea At the Centre for Mathematical Sciences	No Room Required
15:40 to 16:20	Olaf Wolkenhauer System theoretic models of gene expression and gene interactions Meeting room 2 at the Centre for Mathematical Sciences	No Room Required
16:20 to 16:45	Funding opportunities in bioinformatics and theoretical biology Meeting room 2 at the Centre for Mathematical Sciences	No Room Required
16:45 to 17:20	Discussion Session Meeting room 2 at The Centre for Mathematical Sciences	No Room Required
19:00 to 00:00	Dinner at Wolfson Court (residents only)	No Room Required

Wednesday 26th September 2001
10:00 to 11:00	Julian Lewis Notch signalling in spatial and temporal patterning	Room 1
11:00 to 11:30	Coffee	No Room Required
11:30 to 12:30	Jonathan Sherratt Heriot-Watt University Extracellular matrix alignment by cells: discrete and continuous models compared	Room 1
12:30 to 13:30	Lunch	No Room Required
14:30 to 15:30	Paul Kulesa CALTECH (California Institute of Technology) In vivo imaging as a bridge between molecular, cellular and tissue level data in embryonic vertebrate development	Room 1
15:30 to 16:00	Tea	No Room Required
16:00 to 17:00	Raimond Winslow Intracellular calicum cycling and control of action potential duration	Room 1
19:00 to 00:00	Dinner at Wolfson Court (residents only)	No Room Required

Thursday 27th September 2001
10:00 to 11:00	Ray Keller University of Virginia Mechanisms, variation, conservation, and integration of early morphogenic machanies in vertebrates	Room 1
11:00 to 11:30	Coffee	No Room Required
11:30 to 12:30	Richard Adams University of Bath Cell movements during early zebrafish morphogenesis	Room 1
12:30 to 13:30	Lunch	No Room Required
14:30 to 15:30	Kees Weijer University of Dundee The control of cell movement during Dictyostelium morphogenesis	Room 1
15:30 to 16:00	Tea	No Room Required
16:00 to 17:00	Peter Hunter University of Auckland Physiome Projects: The heart, lungs and musculo-skeletal system	Room 1
20:00 to 00:00	Conference Dinner at Robinson College	No Room Required

Friday 28th September 2001
09:00 to 10:00	Frances Ashcroft University of Oxford ATP-sensitive K-channels and insulin secretion in health and disease	Room 1
10:00 to 11:00	Denis Noble University of Oxford From genes to whole organs: vertical integration using mathematical simulation of the heart	Room 1
11:00 to 11:30	Coffee	No Room Required
11:30 to 12:30	Closing discussion and closing remarks	Room 1
12:30 to 13:30	Lunch	No Room Required
19:00 to 00:00	Dinner at Wolfson Court (residents only)	No Room Required

Speakers

Richard Adams University of Bath
Frances Ashcroft University of Oxford
Hamid Bolouri University of Hertfordshire
Alvis Brazma
Helen Causton MRC Clinical Sciences Centre
Gabor Forgacs University of Missouri
Peter Hunter University of Auckland
Ray Keller University of Virginia
Paul Kulesa CALTECH (California Institute of Technology)
Julian Lewis
Denis Noble University of Oxford
Jonathan Sherratt Heriot-Watt University
Keith Vass University of Glasgow
George Von Dassow University of Washington
Kees Weijer University of Dundee
Raimond Winslow
Olaf Wolkenhauer

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Vertical integration in biology: from molecules to organisms

Workshop theme

Timetable

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