Statistical mechanics of molecular and cellular biological systems
SMC
19 January 2004 to 9 July 2004
Programme theme
We are currently witnessing a remarkable period of interaction between physics and biology. Not for the first time are there very good reasons for synergy the beginnings of molecular biology itself emerged from a previous period in which techniques from physics demonstrated huge potential to answer biological questions. The current surge of interest is remarkable because new experimental tools (single-molecule spectroscopy, AFM, fluorescence microscopy, micro-rheology etc.) are accompanied by a powerful body of mathematical techniques arising from the Statistical Mechanics of Soft Matter.
The distinctive issues of this programme, of four sub-themes, arise at the sub-micron domain in which Brownian Motion becomes important; where biochemical processes work with (or against) the tendency to approach thermodynamic equilibrium. Throughout is the creative tension between highly-evolved and specific biological form and function on the one hand, and the overarching statistical mechanics on the other.
The programme will structured along four linked themes:
- Single molecule biophysics (including protein dynamics, mechanical force spectroscopy)
- Membrane/cortical dynamics and self-assembly (including lipid phase separation. Motility and interaction with the extracellular matrix).
- Molecular motors (including modelling of single-molecule motors in the presence of noise, cooperative behaviour, etc.)
- Molecular and cellular aspects of gene expression (including DNA binding proteins and complexes, cell division, trans-membrane signalling, networks or polymerisation and depolymerisation).
While all four will be worked on throughout the 6-month period, there will be periods of more focus on each, when the theoretically-based scientists and mathematicians of the long-term programme will be visited on a shorter-term basis by key experimentalists working in these areas and their boundaries
Thematic Diary
- 22 January - 6 March
- Single molecules and motors
- 15 - 19 March
- Protein folding week
- 29 March - 8 April
- Soft Condensed Matter Physics in Molecular and Cell Biology (A Satellite Meeting at Edinburgh)
- April 12-May 14
- Membranes and membrane interactions
- May 17 - 28
- More on motors
- May 31 - July 9
- Gene regulation
Click here to download the programme's final scientific report
Preprints
| Title | Year | Programme | |
|---|---|---|---|
Lateral phase separation in mixtures of lipids and cholesterol systemsAuthors: H Shirotori, Peter Olmsted, ET Al, Shigeyuki Komura |
2003 | SMC | 21 October 2016 |
Bridging the microscopic and the hydrodynamic in active filament solutionsAuthors: MC Marchetti, TB Liverpool |
2003 | SMC | 21 October 2016 |
Highly specific protein-protein interactions, evolution and negative design (revised edition)Authors: Richard P Sear |
2003 | SMC | 21 October 2016 |
Mathematical models for tubular structures in the papilloma-polyoma family of virusesAuthors: Reidun Twarock |
2003 | SMC | 21 October 2016 |
Flat histogram Monte Carlo for low temperature simulationsAuthors: Lei-Han Tang |
2003 | SMC | 21 October 2016 |
Coarse-grained model of entropic allosteryAuthors: Tom McLeish, R Hawkins |
2003 | SMC | 21 October 2016 |
Multivalent ion driven condensation of DNA-actin polyelectrolyte mixturesAuthors: ET Al, OV Zribi, H Kyung, R Golestanian |
2003 | SMC | 21 October 2016 |
Propulsion of a molecular machine by asymmetric distribution of reaction-productsAuthors: R Golestanian, TB Liverpool, A Ajdari |
2003 | SMC | 21 October 2016 |
Inertial effects in the response of viscous and viscoelastic fluids.Authors: TB Liverpool, FC Mackintosh |
2003 | SMC | 21 October 2016 |
Workshops
Towards a predictive biology
19 January 2004 to 23 January 2004
Focus week on protein folding
15 March 2004 to 19 March 2004
Theoretical and experimental understanding of processive molecular motors
23 March 2004 to 24 March 2004
Soft condensed matter physics in molecular and cell biology
29 March 2004 to 8 April 2004
Special focus week on predicting the structure of biological molecules
26 April 2004 to 30 April 2004
Mathematical virology: theory and experiment for viral assembly
14 June 2004 to 17 June 2004
Protein interactions in vitro and in vivo
21 June 2004 to 23 June 2004
Seminars
| Tuesday 20th January 2004 | |||
|---|---|---|---|
| 17:15 to 18:00 |
Julia Goodfellow Biotechnology and Biological Sciences Research Council (BBSRC) |
Room 2 | |
| Tuesday 27th January 2004 | |||
|---|---|---|---|
| 09:30 to 10:30 |
Alex Levine University of Massachusetts |
Room 1 | |
| Thursday 29th January 2004 | |||
|---|---|---|---|
| 09:30 to 10:30 |
David Dryden |
Room 1 | |
| Tuesday 3rd February 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Pascal Martin |
Room 1 | |
| Thursday 5th February 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 | Room 1 | ||
| Monday 9th February 2004 | |||
|---|---|---|---|
| 11:30 to 13:00 |
Shigeyuki Komura Tokyo Metropolitan University |
Room 2 | |
| Wednesday 11th February 2004 | |||
|---|---|---|---|
| 11:30 to 13:00 |
Frank Juelicher |
Room 2 | |
| Tuesday 17th February 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Artur Baumgaertner |
Room 1 | |
| Wednesday 18th February 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Enrico Carlon |
Room 1 | |
| Thursday 19th February 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 | Room 1 | ||
| Tuesday 24th February 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
David Andelman Tel Aviv University |
Room 1 | |
| Wednesday 25th February 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Shinpei Tanaka |
Room 1 | |
| Thursday 26th February 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Andrej Vilfan |
Room 1 | |
| Tuesday 2nd March 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Tanniemola Liverpool University of Leeds |
Room 1 | |
| 14:00 to 15:00 | Room 1 | ||
| Thursday 4th March 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
The deformations and Green's response of cross-linked biopolymer networks |
Room 1 | |
| Tuesday 9th March 2004 | |||
|---|---|---|---|
| 11:00 to 12:00 | Room 1 | ||
| Wednesday 10th March 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
John Trinick University of Leeds |
Room 1 | |
| 14:00 to 15:00 | Room 1 | ||
| Thursday 11th March 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 | Room 1 | ||
| Wednesday 14th April 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 | Room 1 | ||
| Thursday 15th April 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Jeremy Smith |
Room 1 | |
| Tuesday 20th April 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Eshel Ben-Jacob |
Room 1 | |
| Wednesday 21st April 2004 | |||
|---|---|---|---|
| 11:00 to 12:00 | Room 1 | ||
| Thursday 22nd April 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Anthony Maggs City of Paris Industrial Physics and Chemistry Higher Educational Institution, (ESPCI) |
Room 1 | |
| 15:00 to 16:00 |
Itay Baruchi |
Room 1 | |
| Tuesday 4th May 2004 | |||
|---|---|---|---|
| 14:30 to 15:30 |
Henrik Flyvbjerg |
Room 1 | |
| Wednesday 5th May 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 | Room 1 | ||
| Thursday 6th May 2004 | |||
|---|---|---|---|
| 11:00 to 13:00 |
Satyajit Mayor National Centre for Biological Sciences |
Room 1 | |
| Tuesday 11th May 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Ralph Colby Pennsylvania State University |
Room 1 | |
| Wednesday 12th May 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Artur Baumgaertner |
Room 1 | |
| Thursday 13th May 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Amalie Frischknecht Sandia National Laboratories |
Room 1 | |
| Monday 17th May 2004 | |||
|---|---|---|---|
| 16:00 to 17:00 |
Stefan Egelhaaf University of Edinburgh |
Room 2 | |
| Tuesday 18th May 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 | Room 2 | ||
| Wednesday 19th May 2004 | |||
|---|---|---|---|
| 09:30 to 11:00 |
Thomas Harder University of Oxford |
Room 2 | |
| 11:30 to 13:00 |
Sarah Keller University of Washington |
Room 2 | |
| 14:00 to 15:30 |
Paul Beales University of Edinburgh |
Room 2 | |
| 16:00 to 17:30 | Room 2 | ||
| Thursday 20th May 2004 | |||
|---|---|---|---|
| 09:30 to 11:00 |
Peter Olmsted University of Leeds |
Room 2 | |
| 11:30 to 13:00 |
Satyajit Mayor National Centre for Biological Sciences |
Room 2 | |
| Friday 21st May 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Hue Sun Chan University of Toronto |
Room 2 | |
| 14:00 to 15:30 |
Modelling lipid rafts: size, shape, and possible involvement in membrane mechano-sensitivity |
Room 2 | |
| Tuesday 25th May 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Igor Potemkin Institute of Mechanics of Moscow State University |
Room 1 | |
| Thursday 27th May 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
David Odde University of Minnesota |
Room 1 | |
| Wednesday 2nd June 2004 | |||
|---|---|---|---|
| 09:30 to 16:00 |
Dennis Bray University of Cambridge |
Room 1 | |
| Thursday 3rd June 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Richard Sear University of Surrey |
Room 1 | |
| Saturday 5th June 2004 | |||
|---|---|---|---|
| 09:00 to 18:00 | Room 1 | ||
| Tuesday 8th June 2004 | |||
|---|---|---|---|
| 11:30 to 12:30 |
Jonathon Howard |
Room 1 | |
| Wednesday 23rd June 2004 | |||
|---|---|---|---|
| 14:00 to 15:00 |
Keith Dunker |
Room 1 | |
| Thursday 24th June 2004 | |||
|---|---|---|---|
| 09:30 to 10:30 | Room 1 | ||
| Tuesday 29th June 2004 | |||
|---|---|---|---|
| 09:30 to 10:30 |
Maintenance and propagation of the blueprint for life Cancer and why DNA matters |
Room 2 | |
| 10:30 to 11:30 |
Maintenance and propagation of the blueprint for life The nuts and bolts of DNA replication |
Room 2 | |
| 11:45 to 12:45 | Room 2 | ||
| 13:45 to 14:45 |
Maintenance and propagation of the blueprint for life Packaging of DNA and the problems it presents |
Room 2 | |
| Wednesday 7th July 2004 | |||
|---|---|---|---|
| 09:30 to 10:30 |
Robert Possee |
Room 1 | |
| 10:30 to 11:30 |
Roderick Casey John Innes Centre, Norwich |
Room 1 | |
| 12:00 to 12:30 |
Jonathan Doye University of Cambridge |
Room 1 | |
Organisers
- Thomas Duke University of Cambridge
- Tom McLeish University of Leeds
- Justin Molloy
- Wilson Poon University of Edinburgh
- Peter Stockley University of Leeds
- John Trinick University of Leeds
Speakers
- David Andelman Tel Aviv University
- Itay Baruchi
- Artur Baumgaertner
- Paul Beales University of Edinburgh
- Eshel Ben-Jacob
- Dennis Bray University of Cambridge
- Enrico Carlon
- Roderick Casey John Innes Centre, Norwich
- Hue Sun Chan University of Toronto
- Ralph Colby Pennsylvania State University
- Jonathan Doye University of Cambridge
- David Dryden
- Keith Dunker
- Stefan Egelhaaf University of Edinburgh
- Henrik Flyvbjerg
- Amalie Frischknecht Sandia National Laboratories
- Julia Goodfellow Biotechnology and Biological Sciences Research Council (BBSRC)
- Thomas Harder University of Oxford
- Jonathon Howard
- Frank Juelicher
- Sarah Keller University of Washington
- Shigeyuki Komura Tokyo Metropolitan University
- Alex Levine University of Massachusetts
- Tanniemola Liverpool University of Leeds
- Anthony Maggs City of Paris Industrial Physics and Chemistry Higher Educational Institution, (ESPCI)
- Pascal Martin
- Satyajit Mayor National Centre for Biological Sciences
- David Odde University of Minnesota
- Peter Olmsted University of Leeds
- Robert Possee
- Igor Potemkin Institute of Mechanics of Moscow State University
- Richard Sear University of Surrey
- Jeremy Smith
- Shinpei Tanaka
- John Trinick University of Leeds
- Andrej Vilfan
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