TODW02
3 September 2012 to 7 September 2012
This meeting will provide a forum for biological scientists, physicists and mathematicians to discuss recent developments in the application of topology to the study of DNA and protein structure.
The structure and function of DNA and proteins are affected by the topology of the DNA strands or polypeptide chains, respectively. During DNA replication, transcription or recombination, DNA molecules become supercoiled, knotted or catenated. These processes are dynamic and are modulated by the activity of site-specific recombinases, which break double stranded DNA at a specific locations, and re-assort and rejoin the ends, and DNA topoisomerases, which permit intra- or inter-molecular strand passages by mechanisms also involving the breaking and rejoining of the DNA backbone. The transient DNA breaks induced by topoisomerases have made them a fruitful target for cytotoxic antibacterial and anti-tumour drugs. Recent structural and biochemical studies have elucidated many mechanistic details of both topoisomerases and recombinases.
While supercoiling, knotting and catenation have been intensively studied for over 40 years, the realization that proteins can also be knotted dates back just one decade. The number of known proteins that form knots in their native structure is growing and we are beginning to understand how knotted proteins can fold, and the potential structural advantages of knotted proteins.
Subjects to be covered will include:
Note: over 10 slots are reserved for 15 min talks that will be selected based on submitted abstracts.
An Independent Meeting of the Biochemical Society
NAR awards for the best student presentations and posters
Background image: 110bp minicircle and counter ions (NAR, 39, 3928-38, 2011). Courtesy of Jonathan S Mitchell and Sarah A Harris.
Monday 3rd September 2012 | |||
---|---|---|---|
08:30 to 09:00 | No Room Required | ||
09:00 to 09:10 | Room 1 | ||
09:10 to 09:50 |
Tamar Schlick New York University |
Room 1 | |
09:50 to 10:10 | No Room Required | ||
10:10 to 10:50 |
Makkuni Jayaram Japan Atomic Energy Agency & University of Texas at Austin |
Room 1 | |
10:50 to 11:30 |
Erez Lieberman Aiden Harvard University |
Room 1 | |
11:30 to 12:10 |
Leonid Mirny Massachusetts Institute of Technology |
Room 1 | |
12:30 to 13:30 | Room 1 | ||
13:30 to 14:10 |
Mario Nicodemi Università degli Studi di Napoli Federico II |
Room 1 | |
14:10 to 14:50 |
Stephen D Levene University of Texas at Dallas |
Room 1 | |
14:50 to 15:20 | No Room Required | ||
15:20 to 15:40 |
Luca Giorgetti Institut Curie |
Room 1 | |
15:40 to 16:00 |
Francesca Maggioni Università degli studi di Bergamo |
Room 1 | |
16:00 to 16:20 |
Angelo Rosa SISSA |
Room 1 | |
16:20 to 17:00 |
Nancy Kleckner Harvard University |
Room 1 | |
17:00 to 18:00 | No Room Required | ||
18:00 to 18:30 | No Room Required |
Tuesday 4th September 2012 | |||
---|---|---|---|
08:30 to 09:10 |
Sophie Jackson University of Cambridge |
Room 1 | |
09:10 to 09:50 |
Christian Micheletti SISSA |
Room 1 | |
09:50 to 10:10 | No Room Required | ||
10:10 to 10:50 |
Marek Cieplak Polish Academy of Sciences |
Room 1 | |
10:50 to 11:30 |
Joanna Sulkowska University of California, San Diego |
Room 1 | |
11:30 to 11:50 |
Alexander Kister Rutgers, The State University of New Jersey |
Room 1 | |
11:50 to 12:10 |
Piotr Szymczak Uniwersytet Warszawski |
Room 1 | |
12:30 to 13:30 | No Room Required | ||
13:30 to 14:10 |
Peter Virnau Johannes Gutenberg-Universität Mainz |
Room 1 | |
14:10 to 14:50 |
Kai Ishihara Yamaguchi University |
Room 1 | |
14:50 to 15:20 | No Room Required | ||
15:20 to 15:40 |
Peter Cifra Slovak Academy of Sciences |
Room 1 | |
15:40 to 16:00 |
Tetsuo Deguchi Ochanomizu University |
Room 1 | |
16:00 to 16:20 |
Influence of topology in coarse-graining of polymer solutions |
Room 1 | |
16:20 to 17:00 |
Kenneth Millett University of California, Santa Barbara |
Room 1 | |
17:00 to 17:40 |
Eric Rawdon University of St. Thomas, Minnesota |
Room 1 | |
18:00 to 18:30 | No Room Required |
Wednesday 5th September 2012 | |||
---|---|---|---|
08:30 to 09:10 |
Craig Benham University of California, Davis |
Room 1 | |
09:10 to 09:50 |
Charles Dorman Trinity College Dublin |
Room 1 | |
09:50 to 10:10 | No Room Required | ||
10:10 to 10:50 |
Andrew Travers University of Cambridge |
Room 1 | |
10:50 to 11:30 |
Lynn Zechiedrich Baylor College of Medicine |
Room 1 | |
11:30 to 11:50 |
Greg Chirikjian Johns Hopkins University |
Room 1 | |
11:50 to 12:10 |
Ruggero Cortini Imperial College London |
Room 1 | |
12:30 to 13:30 | No Room Required | ||
13:30 to 14:10 |
Lucy Lifschitz University of Virginia |
Room 1 | |
14:10 to 14:50 |
Krystyna Zakrzewska Université Paris 7 - Denis-Diderot |
Room 1 | |
14:50 to 15:20 | No Room Required | ||
15:20 to 15:40 |
Jonathan Baxter University of Sussex |
Room 1 | |
15:40 to 16:00 |
Andreas Hanke University of Texas at Brownsville |
Room 1 | |
16:00 to 16:20 |
Jakob Bohr Technical University of Denmark |
Room 1 | |
16:20 to 17:00 |
David Swigon University of Pittsburgh |
Room 1 | |
17:00 to 17:40 |
Wilma Olson Rutgers, The State University of New Jersey |
Room 1 | |
17:40 to 19:00 | Discussion Room | ||
19:30 to 22:00 | No Room Required |
Thursday 6th September 2012 | |||
---|---|---|---|
09:10 to 09:50 |
Tony Maxwell John Innes Centre, Norwich |
Room 1 | |
09:50 to 10:10 | No Room Required | ||
10:10 to 10:50 |
Alfonso Mondragón Northwestern University |
Room 1 | |
10:50 to 11:30 |
Chris Soteros University of Saskatchewan |
Room 1 | |
11:30 to 11:50 |
Topo IV is the topoisomerase that knots and unknots sister duplexes during DNA replication |
Room 1 | |
11:50 to 12:10 |
Piotr Sulkowski Universiteit van Amsterdam |
Room 1 | |
12:30 to 13:30 | No Room Required | ||
13:30 to 14:10 |
Giovanni Dietler Centre de Physique Théorique de l’Ecole Polytechnique (CPHT) |
Room 1 | |
14:10 to 14:50 |
Chris Brackley University of Edinburgh |
Room 1 | |
14:50 to 17:40 | No Room Required | ||
18:00 to 18:30 | No Room Required |
Friday 7th September 2012 | |||
---|---|---|---|
08:30 to 09:10 |
Sean Colloms University of Glasgow |
Room 1 | |
09:10 to 09:50 |
Ian Grainge University of Newcastle, Australia |
Room 1 | |
09:50 to 10:10 | No Room Required | ||
10:10 to 10:50 |
Isabel Darcy University of Iowa |
Room 1 | |
10:50 to 11:30 |
Mariel Vazquez San Francisco State University |
Room 1 | |
11:30 to 11:50 |
Rob Scharein Hypnagogic Software |
Room 1 | |
11:50 to 12:10 | Room 1 | ||
12:30 to 13:30 | No Room Required | ||
18:00 to 18:30 | No Room Required |
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