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The role of the cytoskeleton in intracellular signalling

Date: 
Monday 24th September 2001 - 14:40 to 15:40
Venue: 
INI Seminar Room 1
Session Title: 
Vertical Integration in Biology: From Molecules to Organisms
Abstract: 
The cytoskeleton of eucaryotic cells represents an interconnected network of actin filaments, microtubulus and intemediate filaments, which extends over the entire cell. It has long been known that this network regulates cell motility, cell shape, gene expression and a number of other cell functions. Recently it has been recognized that mechanical forces may regulate intracellular signaling pathways and it has been suggested this may involve the cytoskeleton. On one hand the cytoskeleton provides docking sites for many signaling molecules, on the other hand, due to its interconnected character is capable to transmit mechanical signals between distinct parts of the cell. This dual role makes the cytoskeleton an ideal mechano-chemical conversion apparatus. The specific way, how the cytoskeleton may participate in intracellular signaling is not known. I will first show, using information from protein data basis and interaction networks that indeed there is a strong correlation between signaling molecules and cytoskeleton associated molecules. I will then present models for the specific mechanisms of the cytoskeleton's involvement in intracellular signal transduction.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons