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The times' tables of viral resistance

Presented by: 
S Bonhoeffer [Zürich]
Monday 10th December 2001 - 14:30 to 15:30
INI Seminar Room 1
Session Title: 
Immunology, Ecology and Epidemiology (main themes)
Simple population biological models have been instrumental in uncovering the highly dynamic nature of HIV replication in infected patients. These models can be extended to study the dynamics of the evolution of drug resistance in treated individuals. In my talk I will first give an introduction into the basics of these models. I will then discuss some general properties of virus resistance models and put them into the context of relevant biological data. I will apply quasispecies theory to virus dynamical models to investigate the mutation-selection process and its consequences for viral diversity before and during therapy. Finally I will discuss how fitness differences between competing viral variants can be estimated reliably from experimental data.
University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons